Glutathione‐Responsive Near‐Infrared‐II Fluorescence Probe for Early and Accurate Detection of In Situ and Metastatic Tumors

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 21; no. 30; pp. e2503257 - n/a
• Main Authors: Yin, Likun, Xu, Pu, Huang, Yuxin, Gu, Xuxuan, Sun, Liwen, Zhou, Hui, Zhou, Wen, Xie, Chen, Fan, Quli
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.07.2025
• Subjects: activatable probe; Animals; Cell Line, Tumor; Cyanine dyes; Female; Fluorescent Dyes - chemistry; Fluorescent indicators; Glutathione; Glutathione - metabolism; Humans; In vivo methods and tests; Infrared windows; Liver; liver metastases detection; Liver Neoplasms - diagnosis; Liver Neoplasms - secondary; Medical imaging; Metastasis; Mice; Mice, Nude; Near infrared radiation; Neoplasm Metastasis; NIR‐II fluorescence imaging; Oligopeptides - chemistry; osteosarcoma imaging; Polyethylene glycol; Polyethylene Glycols - chemistry; tumor targeting; Tumors; osteosarcoma imaging; activatable probe; liver metastases detection; NIR‐II fluorescence imaging; tumor targeting

In situ and metastatic malignant tumors are primary diseases that threaten human life. Among all the metastases, liver metastasis is the most difficult to detect. As most imaging probes have high liver accumulation, it is difficult to distinguish tiny metastases from normal liver tissue with strong...