Palladium complexes of bidentate pyridine N‐heterocyclic carbenes: Optical resolution, antimicrobial and cytotoxicity studies

• Published in: Applied organometallic chemistry Vol. 32; no. 8
• Main Authors: Choo, Kar Bee, Mah, Wee Li, Lee, Sui Mae, Lee, Wai Leng, Cheow, Yuen Lin
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01.08.2018
• Subjects: Antiinfectives and antibacterials; antimicrobial activity; Biocompatibility; Biomedical materials; Cancer; Carbenes; Chemistry; Chirality; Colon; Cytotoxicity; Microorganisms; N‐heterocyclic carbene; Palladium; palladium NHC complexes; Toxicity

A series of bidentate pyridine‐functionalized palladium N‐heterocyclic carbene (Pd NHC) complexes with various wingtip substituents (R = methyl, phenyl and tert‐butyl) have been synthesized and evaluated for their potential biomedical applications as antimicrobials and antiproliferative drug candida...