MicroRNA‐181a, a potential diagnosis marker, alleviates acute graft versus host disease by regulating IFN‐γ production

• Published in: American journal of hematology Vol. 90; no. 11; pp. 998 - 1007
• Main Authors: Sang, Wei, Zhang, Cong, Zhang, Dianzheng, Wang, Ying, Sun, Cai, Niu, Mingshan, Sun, Xiaoshen, Zhou, Cui, Zeng, Lingyu, Pan, Bin, Chen, Wei, Yan, Dongmei, Zhu, Feng, Wu, Qingyun, Cao, Jiang, Zhao, Kai, Chen, Chong, Li, Zhenyu, Li, Depeng, Loughran, Thomas P., Xu, Kailin
• Format: Journal Article
• Language: English
• Published: United States 01.11.2015
• Subjects: Acute Disease; Adolescent; Adult; Animals; Biomarkers - metabolism; Disease Models, Animal; Female; Gene Expression Regulation; Graft vs Host Disease - diagnosis; Graft vs Host Disease - genetics; Graft vs Host Disease - immunology; Graft vs Host Disease - mortality; Hematopoietic Stem Cell Transplantation; Humans; Interferon-gamma - genetics; Interferon-gamma - immunology; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; MicroRNAs - genetics; MicroRNAs - immunology; Middle Aged; Prognosis; Signal Transduction; Survival Analysis; Transplantation, Homologous; Whole-Body Irradiation

Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a valuable therapeutic strategy for a wide variety of diseases. Acute graft‐versus‐host disease (aGVHD) is a major complication in up to 75% of allo‐HSCT. The absence of a reliable predicative marker for aGVHD onset prevents preemptiv...