Protective immunity against infectious spleen and kidney necrosis virus induced by mannose modified subunit vaccine with carbon nanotubes in mandarin fish

• Published in: Aquaculture research Vol. 53; no. 6; pp. 2175 - 2184
• Main Authors: Zhao, Zhao, Li, Yang, Chen, Guo, Zhang, Chen, Wang, Gao‐Xue, Zhu, Bin
• Format: Journal Article
• Language: English
• Published: Oxford John Wiley & Sons, Inc 01.04.2022
• Subjects: Adjuvants; Antibodies; Antigens; aquaculture; Capsid protein; Carbon; carbon nanotubes; China; coat proteins; Disease control; Economic impact; Economics; Enzymatic activity; Enzyme activity; Enzymes; Fish; Fish diseases; Gene expression; Genes; Host range; Immune response; Immunity; Immunization; Immunogenicity; Immunosuppressive agents; Infectious spleen and kidney necrosis virus; Kidneys; mandarin fish; Mannans; Mannose; mortality; Nanotechnology; Nanotubes; Necrosis; Proteins; Single wall carbon nanotubes; Spleen; subunit vaccine; subunit vaccines; SWCNTs; Vaccines; Viruses; China

Due to its wide host range and frequently causing significant mortality, infectious spleen and kidney necrosis virus (ISKNV) has caused huge economic losses on mandarin fish in China. There are no commercial drugs to cure ISKNV, and vaccines are regarded as one of the most effective measures to cont...