Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection

• Published in: Nature microbiology Vol. 5; no. 10; pp. 1271 - 1284
• Main Authors: Heim, Cortney E., Bosch, Megan E., Yamada, Kelsey J., Aldrich, Amy L., Chaudhari, Sujata S., Klinkebiel, David, Gries, Casey M., Alqarzaee, Abdulelah A., Li, Yixuan, Thomas, Vinai C., Seto, Edward, Karpf, Adam R., Kielian, Tammy
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2020; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/21; 13/31; 38/39; 38/91; 631/250/255; 631/250/262; 631/326/41; 631/326/46; 64/110; 64/60; Acetylation; Bacteria; Biofilms; Biomarkers; Biomedical and Life Sciences; Biosynthetic Pathways; Cell culture; Cytokines - metabolism; Epigenetics; Histone deacetylase; Histone Deacetylases - metabolism; Host-Pathogen Interactions - immunology; Immune response; Infectious Diseases; Inflammation Mediators - metabolism; Interleukin 10; Joint diseases; Lactic acid; Lactic Acid - metabolism; Life Sciences; Macrophages; Macrophages - immunology; Macrophages - metabolism; Medical Microbiology; Microbiology; Monocytes; Mutants; Myeloid-Derived Suppressor Cells - immunology; Myeloid-Derived Suppressor Cells - metabolism; Parasitology; Penicillin; Staphylococcal Infections - immunology; Staphylococcal Infections - metabolism; Staphylococcal Infections - microbiology; Staphylococcus aureus; Staphylococcus aureus - physiology; Suppressor cells; Synovial fluid; Transcription; Virology

Staphylococcus aureus is a leading cause of biofilm-associated prosthetic joint infection (PJI), resulting in considerable disability and prolonged treatment. It is known that host leukocyte IL-10 production is required for S. aureus biofilm persistence in PJI. An S. aureus bursa aurealis Tn library...