The association between white matter hyperintensities, cognition and regional neural activity in healthy subjects

• Published in: The European journal of neuroscience Vol. 54; no. 4; pp. 5427 - 5443
• Main Authors: Porcu, Michele, Cocco, Luigi, Cocozza, Sirio, Pontillo, Giuseppe, Operamolla, Annunziata, Defazio, Giovanni, Suri, Jasjit S., Brunetti, Arturo, Saba, Luca
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01.08.2021
• Subjects: Aging; Brain mapping; Cerebellum; Cognition; Cognition & reasoning; Cognitive ability; Cortex (parietal); Functional magnetic resonance imaging; functional MRI; Neuroimaging; Prefrontal cortex; Statistical analysis; Structure-function relationships; Substantia alba; white matter hyperintensities
• ISSN: 0953-816X; 1460-9568; 1460-9568
• DOI: 10.1111/ejn.15403

White matter hyperintensities (WMH) are common findings that can be found in physiological ageing. Several studies suggest that the disruption of white matter tracts included in WMH could induce abnormal functioning of the respective linked cortical structures, with consequent repercussion on the ce...