Lupus Nephritis: Glycogen Synthase Kinase 3β Promotion of Renal Damage Through Activation of the NLRP3 Inflammasome in Lupus‐Prone Mice

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 67; no. 4; pp. 1036 - 1044
• Main Authors: Zhao, Jijun, Wang, Hongyue, Huang, Yuefang, Zhang, Hui, Wang, Shuang, Gaskin, Felicia, Yang, Niansheng, Fu, Shu Man
• Format: Journal Article
• Language: English
• Published: United States 01.04.2015
• Subjects: Animals; Carrier Proteins - metabolism; Cell Line; Glycogen Synthase Kinase 3 - antagonists & inhibitors; Glycogen Synthase Kinase 3 - metabolism; Glycogen Synthase Kinase 3 beta; Inflammasomes - metabolism; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Lupus Nephritis - metabolism; Lupus Nephritis - pathology; Macrophages - drug effects; Macrophages - metabolism; Macrophages - pathology; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Proteinuria - metabolism; Proteinuria - pathology; Signal Transduction - drug effects; Signal Transduction - physiology; Thiadiazoles - pharmacology

Objective Glycogen synthase kinase 3β (GSK‐3β) has been demonstrated to be involved in immune and inflammatory responses via multiple signaling pathways, leading to the production of proinflammatory cytokines. The purpose of this study was to investigate the role of GSK‐3β in the pathogenesis of lup...