A Multiple Biological Activities Cyclopeptide From Endophytic Fungus Phaeosphaeria Sp. XXH003 of the Marine Conus literatus

• Published in: Chemistry & biodiversity Vol. 22; no. 8; pp. e202403141 - n/a
• Main Authors: Lin, Ying‐ting, Liu, Jie, Huang, Zhou, Hu, An‐qi, Liu, Yu‐hang, Zhang, Zhi‐hao, Dong, Shuai
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.08.2025
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Ascomycota - chemistry; bioactivities; Caenorhabditis elegans - drug effects; Cell culture; Cell Line, Tumor; Collagen (type I); Conus; Conus literatus; cyclopeptide; Depsipeptides - chemistry; Depsipeptides - isolation & purification; Depsipeptides - pharmacology; Dose-Response Relationship, Drug; Endophytes; Ergosterol; Ergosterol - chemistry; Fibronectin; Fibrosis; Fungi; Fungi - chemistry; Glioma cells; Herpes simplex; Humans; Life span; Linoleic acid; Marine chemistry; Mass spectrometry; Mass spectroscopy; Molecular Structure; Neuroprotection; NMR; Nuclear magnetic resonance; Oleic acid; Peptides, Cyclic - chemistry; Peptides, Cyclic - isolation & purification; Peptides, Cyclic - pharmacology; Phaeosphaeria; Phaeosphaeria sp; Plant viruses; secondary metabolites; Stomatitis; Structure-Activity Relationship; Vimentin; secondary metabolites; Conus literatus; Phaeosphaeria sp; cyclopeptide; bioactivities

ABSTRACT Chemical investigation of the endophytic fungus Phaeosphaeria sp. XXH003 isolated from Conus literatus was conducted. Eleven compounds were isolated and identified as ergosterol (1), β‐sitosterol (2), ergosterol peroxide (3), ergosta‐4,6,8(14),22‐tetraen‐3‐one (4), 1,1'‐oxybis(2,4‐di‐t...