A KCNQ4 c.546C>G Genetic Variant Associated with Late Onset Non-Syndromic Hearing Loss in a Taiwanese Population

• Published in: Genes Vol. 12; no. 11; p. 1711
• Main Authors: Yen, Ting-Ting, Chen, I-Chieh, Hua, Men-Wei, Wei, Chia-Yi, Shih, Kai-Hsiang, Li, Jui-Lin, Lin, Ching-Heng, Hsiao, Tzu-Hung, Chen, Yi-Ming, Jiang, Rong-San
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.10.2021; MDPI
• Subjects: Adult; Age; Age Factors; Age of Onset; Aged; Aortic aneurysms; Asians - genetics; Audiometry, Pure-Tone; Biobanks; Case-Control Studies; Deafness - genetics; Diabetes mellitus; Disease; Female; Genes; Genetic counseling; Genetic diversity; Genome-Wide Association Study; Hearing loss; Hearing protection; Hospitals; Humans; KCNQ Potassium Channels - genetics; KCNQ4 protein; Male; Middle Aged; Mutation; Otolaryngology; Outpatient care facilities; Patients; Phenomics; Phenotypes; Polymorphism, Single Nucleotide; Polyneuropathy; Population; Population genetics; Potassium; Potassium channels (voltage-gated); Precision medicine; Taiwan - epidemiology; Tinnitus; Tinnitus - epidemiology; Tinnitus - genetics; Vertigo; Vertigo - epidemiology; Vertigo - genetics; Taiwan; United States > US; pure tone audiometry; KCNQ4 c.546C>G; audiograms; autosomal dominant nonsyndromic hearing loss

Clinical presentation is heterogeneous for autosomal dominant nonsyndromic hearing loss (ADNSHL). Variants of gene is a common genetic factor of ADNSHL. Few studies have investigated the association between hearing impairment and the variant c.546C>G of . Here, we investigated the phenotype and c...