Genetic polymorphism of the adenosine A₂A receptor is associated with habitual caffeine consumption

• Published in: The American journal of clinical nutrition Vol. 86; no. 1; pp. 240 - 244
• Main Authors: Cornelis, Marilyn C, El-Sohemy, Ahmed, Campos, Hannia
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Nutrition 01.07.2007; American Society for Clinical Nutrition
• Subjects: adenosine; Alcohol Drinking; alleles; Biological and medical sciences; caffeine; Caffeine - administration & dosage; Case-Control Studies; Costa Rica; cytochrome P-450; Cytochrome P-450 CYP1A2 - genetics; Cytochrome P-450 CYP1A2 - metabolism; DNA - chemistry; DNA - genetics; Drinking Behavior - physiology; epidemiology; Feeding. Feeding behavior; Female; food frequency questionnaires; food intake; Fundamental and applied biological sciences. Psychology; genetic polymorphism; Genetic Variation; Genotype; Humans; Logistic Models; Male; mechanism of action; Middle Aged; nutrition-genotype interaction; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; receptors; Receptors, Adenosine A2 - genetics; Receptors, Adenosine A2 - metabolism; Smoking; smoking (habit); stimulant plants; Substance-Related Disorders - genetics; Substance-Related Disorders - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Costa Rica; Human; Cytochrome P450; cytochrome P450 1A2; Genotype; adenosine A2A receptor gene; Epidemiology; Gene; ADORA2A; Food intake; Dependence; CYP1A2; Genetics; Adenosine receptor; Caffeine; Polymorphism

BACKGROUND: Caffeine is the most widely consumed stimulant in the world, and individual differences in response to its stimulating effects may explain some of the variability in caffeine consumption within a population. OBJECTIVE: We examined whether genetic variability in caffeine metabolism [cytoc...