Genetic associations between bipolar disorder and brain structural phenotypes

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 33; no. 11; pp. 6990 - 7000
• Main Authors: Shang, Meng-Yuan, Zhang, Chu-Yi, Wu, Yong, Wang, Lu, Wang, Chuang, Li, Ming
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 24.05.2023
• Subjects: Bipolar Disorder - genetics; Brain - diagnostic imaging; Genetic Loci; Genetic Predisposition to Disease - genetics; Genome-Wide Association Study; GTP-Binding Proteins - genetics; Humans; Nuclear Proteins - genetics; Phenotype; Polymorphism, Single Nucleotide - genetics; bipolar disorder; neurodevelopmental hypothesis; brain structural phenotypes; shared genetic basis; genome-wide association study

Abstract Patients with bipolar disorder (BD) and their first-degree relatives exhibit alterations in brain volume and cortical structure, whereas the underlying genetic mechanisms remain unclear. In this study, based on the published genome-wide association studies (GWAS), the extent of polygenic ov...