Mesenchymal Stromal Cells from Human Wharton’s Jelly Modulate the Intraocular Immune Response in a Glucocorticoid Hypertension Model: An Exploratory Analysis

• Published in: Ophthalmic research Vol. 67; no. 1; pp. 232 - 247
• Main Authors: dos Santos Evangelho, Karine, Cifuentes-González, Carlos, Rojas-Carabali, William, De Vivero-Arciniegas, Clemencia, Cañas-Arboleda, Mariana, Salguero, Gustavo, Ramírez-Santana, Carolina, de-la-Torre, Alejandra
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 08.03.2024
• Subjects: Animals; Aqueous Humor - metabolism; Cytokines - metabolism; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glucocorticoids; Humans; Immunohistochemistry; Intraocular Pressure - physiology; Intravitreal Injections; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stem Cells; Ocular Hypertension - metabolism; Optic Nerve - pathology; Rabbits; Research Article; Retinal Ganglion Cells - pathology; Wharton Jelly - cytology; Glaucoma; Mesenchymal stromal cells; Immune response; Human Wharton’s jelly; Cytokine

Abstract Introduction: Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells. Recent research suggests immunological changes such as cytokine imbalance may affect its pathophysiology. This implies that immunomodulation, like that of mesenchymal cells, could be a...