An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water

• Published in: Green chemistry : an international journal and green chemistry resource : GC Vol. 22; no. 12; pp. 3716 - 3720
• Main Authors: Lei, Jie, Li, Yong, Xu, Jia, Tang, Dian-Yong, Shao, Jing-Wei, Li, Hong-yu, Chen, Zhong-Zhu, Xu, Zhi-Gang
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 22.06.2020; Royal Society of Chemistry
• Subjects: Alkenes; Catalysts; catalytic activity; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Crystallography; Green & Sustainable Science & Technology; Green chemistry; hydrogen bonding; Hydrogen bonds; Imines; Physical Sciences; schiff bases; Science & Technology; Science & Technology - Other Topics; FUNCTIONALIZATION; CHEMISTRY; CHROMONE; PYRROLES; DERIVATIVES; UGI

A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol without a metal catalyst. The 1,4-addition of isocyanides occurred at the C-2 position of chromones instead of the Schiff base in neat water. We f...