An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water

A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol without a metal catalyst. The 1,4-addition of isocyanides occurred at the C-2 position of chromones instead of the Schiff base in neat water. We f...

Full description

Saved in:
Bibliographic Details
Published inGreen chemistry : an international journal and green chemistry resource : GC Vol. 22; no. 12; pp. 3716 - 3720
Main Authors Lei, Jie, Li, Yong, Xu, Jia, Tang, Dian-Yong, Shao, Jing-Wei, Li, Hong-yu, Chen, Zhong-Zhu, Xu, Zhi-Gang
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 22.06.2020
Royal Society of Chemistry
Subjects
Alkenes
Catalysts
catalytic activity
Chemical synthesis
Chemistry
Chemistry, Multidisciplinary
Crystallography
Green & Sustainable Science & Technology
Green chemistry
hydrogen bonding
Hydrogen bonds
Imines
Physical Sciences
schiff bases
Science & Technology
Science & Technology - Other Topics
FUNCTIONALIZATION
CHEMISTRY
CHROMONE
PYRROLES
DERIVATIVES
UGI
Online AccessGet full text

Cover

Abstract A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol without a metal catalyst. The 1,4-addition of isocyanides occurred at the C-2 position of chromones instead of the Schiff base in neat water. We found that the hydrogen bond can dictate the stereo-outcome of olefins, providing an effective method for the diastereomer-selective synthesis of this type of chromanone. The novel green synthetic protocol allowed the quick synthesis of complex chromanones in an environmentally friendly manner.
AbstractList A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol without a metal catalyst. The 1,4-addition of isocyanides occurred at the C-2 position of chromones instead of the Schiff base in neat water. We found that the hydrogen bond can dictate the stereo-outcome of olefins, providing an effective method for the diastereomer-selective synthesis of this type of chromanone. The novel green synthetic protocol allowed the quick synthesis of complex chromanones in an environmentally friendly manner.
A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol without a metal catalyst. The 1,4-addition of isocyanides occurred at the C-2 position of chromones instead of the Schiff base in neat water. We found that the hydrogen bond can dictate the stereo-outcome of olefins, providing an effective method for the diastereomer-selective synthesis of this type of chromanone. The novel green synthetic protocol allowed the quick synthesis of complex chromanones in an environmentally friendly manner.
A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanonesviaa facile, mild, and efficient one-pot protocol without a metal catalyst. The 1,4-addition of isocyanides occurred at the C-2 position of chromones instead of the Schiff base in neat water. We found that the hydrogen bond can dictate the stereo-outcome of olefins, providing an effective method for the diastereomer-selective synthesis of this type of chromanone. The novel green synthetic protocol allowed the quick synthesis of complex chromanones in an environmentally friendly manner.
Author Lei, Jie
Xu, Jia
Shao, Jing-Wei
Xu, Zhi-Gang
Li, Yong
Tang, Dian-Yong
Li, Hong-yu
Chen, Zhong-Zhu
Author_xml – sequence: 1
  givenname: Jie
  surname: Lei
  fullname: Lei, Jie
  organization: College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160
– sequence: 2
  givenname: Yong
  surname: Li
  fullname: Li, Yong
  organization: College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160
– sequence: 3
  givenname: Jia
  surname: Xu
  fullname: Xu, Jia
  organization: College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160
– sequence: 4
  givenname: Dian-Yong
  orcidid: 0000-0001-9389-870X
  surname: Tang
  fullname: Tang, Dian-Yong
  organization: College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160
– sequence: 5
  givenname: Jing-Wei
  surname: Shao
  fullname: Shao, Jing-Wei
  organization: Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, USA
– sequence: 6
  givenname: Hong-yu
  surname: Li
  fullname: Li, Hong-yu
  organization: Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, USA
– sequence: 7
  givenname: Zhong-Zhu
  surname: Chen
  fullname: Chen, Zhong-Zhu
  organization: College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160
– sequence: 8
  givenname: Zhi-Gang
  orcidid: 0000-0003-0190-1313
  surname: Xu
  fullname: Xu, Zhi-Gang
  organization: College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160
BookMark eNqNkU9r3DAQxUVJodmkl34CQy8hjdPRH0v2cXGbbWGhl-RsxrIMCl5pI8ksm08fLbtpIeTQ0zx4vzczzCzImfPOEPKFwi0F3nz_AasWQFZs-YGcUyF52TAFZ3-1ZJ_IIsZHAEqVFOfkYekK1HYoNSac9s9mKOiNKHEYbLLeFTZ6vUdnB1P2GLO7madktd9s82CXimBQH0FXOIOp2GEy4ZJ8HHGK5vOpXpCHu5_37a9y_Wf1u12uS81Zk8qhlxq1rrhSdKxZ3QsJkgFV2IyMc1VlC_gwGto3lFbQYCVUrwQbGy1qM_ILcnXsuw3-aTYxdRsbtZkmdMbPsWNCKUml4k1Gv75BH_0cXN4uU7QSUMv6QH07UjvT-zFqa5w23TbYDYZ9BwCVEJwKnhXwTNf_T7c24eFSrZ9dylE4RnXwMQYzdvrkp4B26ih0h4d2_x6aI9dvIq-T3oFfAEv0ni0
CitedBy_id crossref_primary_10_1002_slct_202301448
crossref_primary_10_2174_1570179420666230330170845
crossref_primary_10_1007_s11164_025_05506_7
crossref_primary_10_1002_ajoc_202300502
crossref_primary_10_1039_D3OB01671D
crossref_primary_10_1021_acs_joc_4c01410
crossref_primary_10_1039_D1RA03740D
crossref_primary_10_1016_j_molliq_2021_117800
crossref_primary_10_1021_acs_joc_1c02649
crossref_primary_10_3987_COM_21_14504
crossref_primary_10_1002_ajoc_202200448
crossref_primary_10_1016_j_molstruc_2023_134982
crossref_primary_10_1039_D4OB00329B
crossref_primary_10_3390_molecules28227602
crossref_primary_10_1038_s41598_021_94846_6
crossref_primary_10_3390_molecules25245935
crossref_primary_10_1007_s11030_023_10625_7
crossref_primary_10_1039_D0GC04124F
crossref_primary_10_1007_s11030_024_11027_z
crossref_primary_10_1039_D2OB01034H
crossref_primary_10_1039_D2GC01689C
crossref_primary_10_1021_acs_joc_2c01437
crossref_primary_10_1021_acs_joc_3c02554
crossref_primary_10_1016_j_tetlet_2021_153511
crossref_primary_10_1021_acs_joc_1c02434
crossref_primary_10_1021_acssuschemeng_4c05293
crossref_primary_10_6023_cjoc202403025
Cites_doi 10.1021/ol062773j
10.1039/C9GC03253C
10.1007/s11030-017-9811-2
10.1039/np9860300465
10.1039/B507207G
10.1021/acs.joc.7b02361
10.1039/c3cs35505e
10.1002/(SICI)1521-3773(19980904)37:16<2234::AID-ANIE2234>3.0.CO;2-R
10.1007/s00044-016-1691-y
10.1039/c3ra23087b
10.1021/acs.orglett.5b03529
10.1126/science.aad7893
10.1002/jlac.19636700110
10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U
10.1039/C5RA08059B
10.1021/cr500691k
10.1039/D0QO00145G
10.1039/c2gc35635j
10.1016/S0040-4020(03)01201-8
10.1039/C6CS00444J
10.1002/chem.201603412
10.1039/c3gc42130a
10.1021/ol3033829
10.1039/b205800f
10.1021/jm00013a023
10.1021/ja031770o
10.1016/j.bmc.2009.03.020
10.1039/c2md20089a
10.1002/anie.196200081
10.1039/b006257j
10.1039/C5RA06747B
10.1002/ejoc.200390167
10.1002/chem.201600285
10.1021/ol9001619
10.1021/jo802016t
10.1021/cr400615v
10.1021/ja205891m
10.1021/acs.orglett.6b02493
10.1002/anie.200800494
10.1039/C5RA14988F
10.3390/molecules21010019
10.1002/chem.201000046
10.1021/jacs.6b11188
10.1021/cr100233r
10.1039/c5ra14988f
10.1039/c5ra08059b
10.1039/c5ra06747b
10.1039/c6cs00444j
10.1039/d0qo00145g
10.1039/b507207g
10.1039/c9gc03253c
ContentType Journal Article
Copyright Copyright Royal Society of Chemistry 2020
Copyright_xml – notice: Copyright Royal Society of Chemistry 2020
DBID AAYXX
CITATION
17B
1KN
AOWDO
BLEPL
DTL
EGQ
7SR
7ST
7U6
8BQ
8FD
C1K
JG9
7S9
L.6
DOI 10.1039/D0GC00652A
DatabaseName CrossRef
Web of Knowledge
Current Chemical Reactions
Web of Science - Science Citation Index Expanded - 2020
Web of Science Core Collection
Science Citation Index Expanded
Web of Science Primary (SCIE, SSCI & AHCI)
Engineered Materials Abstracts
Environment Abstracts
Sustainability Science Abstracts
METADEX
Technology Research Database
Environmental Sciences and Pollution Management
Materials Research Database
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
Web of Science
Materials Research Database
Engineered Materials Abstracts
Technology Research Database
Sustainability Science Abstracts
Environment Abstracts
METADEX
Environmental Sciences and Pollution Management
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList Materials Research Database
CrossRef
AGRICOLA
Web of Science
Database_xml – sequence: 1
  dbid: 1KN
  name: Current Chemical Reactions
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.CCR
  sourceTypes:
    Enrichment Source
    Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
Chemistry
Environmental Sciences
EISSN 1463-9270
EndPage 3720
ExternalDocumentID 000544314300003
10_1039_D0GC00652A
GroupedDBID 0-7
0R~
29I
4.4
5GY
705
70~
7~J
AAEMU
AAHBH
AAIWI
AAJAE
AAMEH
AANOJ
AAWGC
AAXHV
AAXPP
AAYXX
ABASK
ABDVN
ABEMK
ABJNI
ABPDG
ABRYZ
ABXOH
ACGFO
ACGFS
ACIWK
ACLDK
ADMRA
ADSRN
AEFDR
AENEX
AENGV
AESAV
AETIL
AFLYV
AFOGI
AFRAH
AFRDS
AFRZK
AFVBQ
AGEGJ
AGKEF
AGRSR
AHGCF
AKMSF
ALMA_UNASSIGNED_HOLDINGS
ALUYA
ANUXI
APEMP
ASKNT
AUDPV
BLAPV
BSQNT
C6K
CITATION
COF
CS3
D0L
DU5
EBS
ECGLT
EE0
EF-
F5P
GGIMP
GNO
H13
HZ~
H~N
IDZ
J3I
M4U
N9A
O9-
P2P
R56
R7B
RAOCF
RCNCU
RNS
RPMJG
RRA
RRC
RSCEA
SKA
SLH
VH6
17B
1KN
BLEPL
DTL
GROUPED_WOS_WEB_OF_SCIENCE
7SR
7ST
7U6
8BQ
8FD
C1K
JG9
7S9
L.6
ID FETCH-LOGICAL-c329t-db6cacc53771f828b46062017a9f23375c5303dfe1b911509a547b742f9c48ef3
ISICitedReferencesCount 31
ISICitedReferencesURI https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=000544314300003
ISSN 1463-9262
1463-9270
IngestDate Fri Jul 11 12:22:45 EDT 2025
Mon Jun 30 11:58:19 EDT 2025
Fri May 30 00:44:37 EDT 2025
Fri Aug 29 16:07:13 EDT 2025
Tue Jul 01 01:41:23 EDT 2025
Thu Apr 24 22:51:54 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 12
Keywords FUNCTIONALIZATION
CHEMISTRY
CHROMONE
PYRROLES
DERIVATIVES
UGI
Language English
LinkModel OpenURL
LogoURL https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg
MergedId FETCHMERGED-LOGICAL-c329t-db6cacc53771f828b46062017a9f23375c5303dfe1b911509a547b742f9c48ef3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0001-9389-870X
0000-0003-0190-1313
PQID 2415408689
PQPubID 2047490
PageCount 5
ParticipantIDs proquest_miscellaneous_2477616739
crossref_citationtrail_10_1039_D0GC00652A
webofscience_primary_000544314300003
webofscience_primary_000544314300003CitationCount
proquest_journals_2415408689
crossref_primary_10_1039_D0GC00652A
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20200622
PublicationDateYYYYMMDD 2020-06-22
PublicationDate_xml – month: 06
  year: 2020
  text: 20200622
  day: 22
PublicationDecade 2020
PublicationPlace CAMBRIDGE
PublicationPlace_xml – name: CAMBRIDGE
– name: Cambridge
PublicationTitle Green chemistry : an international journal and green chemistry resource : GC
PublicationTitleAbbrev GREEN CHEM
PublicationYear 2020
Publisher Royal Soc Chemistry
Royal Society of Chemistry
Publisher_xml – name: Royal Soc Chemistry
– name: Royal Society of Chemistry
References Dömling (D0GC00652A-(cit2d)/*[position()=1]) 2000; 39
Dömling (D0GC00652A-(cit2e)/*[position()=1]) 2012; 112
Żądło-Dobrowolska (D0GC00652A-(cit9f)/*[position()=1]) 2016; 22
Zhang (D0GC00652A-(cit14a)/*[position()=1]) 2016; 351
Zhang (D0GC00652A-(cit11d)/*[position()=1]) 1995; 38
Slobbe (D0GC00652A-(cit1b)/*[position()=1]) 2012; 3
Bousejra-ElGarah (D0GC00652A-(cit11f)/*[position()=1]) 2016; 25
da Silva (D0GC00652A-(cit13d)/*[position()=1]) 2017; 82
Ugi (D0GC00652A-(cit9a)/*[position()=1]) 1962; 1
Lei (D0GC00652A-(cit2a)/*[position()=1]) 2018; 22
Pan (D0GC00652A-(cit9d)/*[position()=1]) 2008; 47
Lei (D0GC00652A-(cit4d)/*[position()=1]) 2020; 7
Cioc (D0GC00652A-(cit2c)/*[position()=1]) 2016; 22
Vidyacharan (D0GC00652A-(cit5c)/*[position()=1]) 2014; 16
Rotstein (D0GC00652A-(cit2f)/*[position()=1]) 2014; 114
Ugi (D0GC00652A-(cit4a)/*[position()=1]) 1963; 670
Yuan (D0GC00652A-(cit13a)/*[position()=1]) 2018
Zhu (D0GC00652A-(cit9c)/*[position()=1]) 2016; 18
Lv (D0GC00652A-(cit9g)/*[position()=1]) 2019; 21
Saengchantara (D0GC00652A-(cit11a)/*[position()=1]) 1986; 3
St. Cyr (D0GC00652A-(cit4b)/*[position()=1]) 2007; 9
Kumar (D0GC00652A-(cit9b)/*[position()=1]) 2013; 3
Dagousset (D0GC00652A-(cit12a)/*[position()=1]) 2011; 133
Um (D0GC00652A-(cit13e)/*[position()=1]) 2010; 16
Wadhwa (D0GC00652A-(cit5b)/*[position()=1]) 2015; 15
Budzisz (D0GC00652A-(cit11c)/*[position()=1]) 2002; 26
Dorel (D0GC00652A-(cit2b)/*[position()=1]) 2015; 115
Brauch (D0GC00652A-(cit2g)/*[position()=1]) 2013; 42
Kłzossowski (D0GC00652A-(cit9e)/*[position()=1]) 2013; 15
Harborne (D0GC00652A-(cit11b)/*[position()=1]) 2001; 18
Fontaine (D0GC00652A-(cit4c)/*[position()=1]) 2009; 11
Zhu (D0GC00652A-(cit1d)/*[position()=1]) 2003
Váradi (D0GC00652A-(cit3)/*[position()=1]) 2016; 21
Giustiniano (D0GC00652A-(cit1a)/*[position()=1]) 2017; 46
Khan (D0GC00652A-(cit10)/*[position()=1]) 2009; 17
Gu (D0GC00652A-(cit7b)/*[position()=1]) 2012; 14
Ugi (D0GC00652A-(cit8)/*[position()=1]) 1959; 71
Hodgson (D0GC00652A-(cit13c)/*[position()=1]) 2009; 74
Hodgson (D0GC00652A-(cit13b)/*[position()=1]) 2004; 126
Cagide (D0GC00652A-(cit11e)/*[position()=1]) 2015; 5
Bienaymé (D0GC00652A-(cit5a)/*[position()=1]) 1998; 37
Khan (D0GC00652A-(cit1c)/*[position()=1]) 2015; 5
Liu (D0GC00652A-(cit14b)/*[position()=1]) 2017; 139
Li (D0GC00652A-(cit7a)/*[position()=1]) 2006; 35
Lu (D0GC00652A-(cit6)/*[position()=1]) 2016; 18
Elassar (D0GC00652A-(cit12b)/*[position()=1]) 2003; 59
Dagousset, G (WOS:000295148100053) 2011; 133
Vidyacharan, S (WOS:000332039200025) 2014; 16
Lei, J (WOS:000434996100014) 2018; 22
Rotstein, BH (WOS:000340992200013) 2014; 114
Dorel, R (WOS:000361254500004) 2015; 115
Elassar, AZA (WOS:000186109100001) 2003; 59
Gu, YL (WOS:000306658200002) 2012; 14
Bienayme, H (WOS:000075860500016) 1998; 37
Hodgson, DM (WOS:000221828200017) 2004; 126
ZHANG, MQ (WOS:A1995RF52600023) 1995; 38
Zhu, JP (WOS:000182125100001) 2003; 2003
Hodgson, DM (WOS:000263004300008) 2009; 74
Kumar, A (WOS:000315905400022) 2013; 3
Yuan, J. (000544314300003.42) 2018
Giustiniano, M (WOS:000396134400004) 2017; 46
UGI, I (WOS:A1959WY43600066) 1959; 71
Wadhwa, P (WOS:000354964900055) 2015; 5
Harborne, JB (WOS:000169554300004) 2001; 18
Domling, A (WOS:000305108600002) 2012; 112
Pan, SC (WOS:000255530100031) 2008; 47
da Silva, MJV (WOS:000417342300061) 2017; 82
Varadi, A (WOS:000369485600008) 2016; 21
Li, CJ (WOS:000234096200006) 2006; 35
Lei, J (WOS:000526910600002) 2020; 7
Budzisz, E (WOS:000179340500017) 2002; 26
Cagide, F (WOS:000361675800023) 2015; 5
Brauch, S (WOS:000319527400008) 2013; 42
UGI, I (WOS:A19634479A00022) 1963; 670
SAENGCHANTARA, ST (WOS:A1986F560400004) 1986; 3
Cioc, RC (WOS:000380267100024) 2016; 22
UGI, I (WOS:A19624242A00074) 1962; 74
Um, JM (WOS:000278880300023) 2010; 16
Liu, XH (WOS:000392459300050) 2017; 139
Zhang, FL (WOS:000368098600035) 2016; 351
Klossowski, S (WOS:000314559000036) 2013; 15
St Cyr, DJ (WOS:000243706400018) 2007; 9
Khan, MM (WOS:000357805500077) 2015; 5
Lu, K (WOS:000385053900072) 2016; 18
do-Dobrowolska, A. (000544314300003.9) 2016; 22
Zhu, ZB (WOS:000370768200001) 2016; 18
Fontaine, P (WOS:000264622600024) 2009; 11
Slobbe, P (WOS:000310423600001) 2012; 3
Khan, KM (WOS:000265044500004) 2009; 17
Lv, YF (WOS:000496489100002) 2019; 21
Bousejra-ElGarah, F (WOS:000386763500011) 2016; 25
Domling, A (WOS:000089433600001) 2000; 39
References_xml – start-page: 1875
  year: 2018
  ident: D0GC00652A-(cit13a)/*[position()=1]
  publication-title: Synthesis
– volume: 9
  start-page: 449
  year: 2007
  ident: D0GC00652A-(cit4b)/*[position()=1]
  publication-title: Org. Lett.
  doi: 10.1021/ol062773j
– volume: 21
  start-page: 6051
  year: 2019
  ident: D0GC00652A-(cit9g)/*[position()=1]
  publication-title: Green Chem.
  doi: 10.1039/C9GC03253C
– volume: 22
  start-page: 503
  year: 2018
  ident: D0GC00652A-(cit2a)/*[position()=1]
  publication-title: Mol. Divers.
  doi: 10.1007/s11030-017-9811-2
– volume: 3
  start-page: 465
  year: 1986
  ident: D0GC00652A-(cit11a)/*[position()=1]
  publication-title: Nat. Prod. Rep.
  doi: 10.1039/np9860300465
– volume: 35
  start-page: 68
  year: 2006
  ident: D0GC00652A-(cit7a)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/B507207G
– volume: 82
  start-page: 12590
  year: 2017
  ident: D0GC00652A-(cit13d)/*[position()=1]
  publication-title: J. Org. Chem.
  doi: 10.1021/acs.joc.7b02361
– volume: 42
  start-page: 4948
  year: 2013
  ident: D0GC00652A-(cit2g)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/c3cs35505e
– volume: 37
  start-page: 2234
  year: 1998
  ident: D0GC00652A-(cit5a)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/(SICI)1521-3773(19980904)37:16<2234::AID-ANIE2234>3.0.CO;2-R
– volume: 25
  start-page: 2547
  year: 2016
  ident: D0GC00652A-(cit11f)/*[position()=1]
  publication-title: Med. Chem. Res.
  doi: 10.1007/s00044-016-1691-y
– volume: 3
  start-page: 4610
  year: 2013
  ident: D0GC00652A-(cit9b)/*[position()=1]
  publication-title: RSC Adv.
  doi: 10.1039/c3ra23087b
– volume: 18
  start-page: 631
  year: 2016
  ident: D0GC00652A-(cit9c)/*[position()=1]
  publication-title: Org. Lett.
  doi: 10.1021/acs.orglett.5b03529
– volume: 351
  start-page: 252
  year: 2016
  ident: D0GC00652A-(cit14a)/*[position()=1]
  publication-title: Science
  doi: 10.1126/science.aad7893
– volume: 670
  start-page: 74
  year: 1963
  ident: D0GC00652A-(cit4a)/*[position()=1]
  publication-title: Liebigs Ann. Chem.
  doi: 10.1002/jlac.19636700110
– volume: 39
  start-page: 3168
  year: 2000
  ident: D0GC00652A-(cit2d)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U
– volume: 5
  start-page: 57883
  year: 2015
  ident: D0GC00652A-(cit1c)/*[position()=1]
  publication-title: RSC Adv.
  doi: 10.1039/C5RA08059B
– volume: 115
  start-page: 9028
  year: 2015
  ident: D0GC00652A-(cit2b)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/cr500691k
– volume: 7
  start-page: 987
  year: 2020
  ident: D0GC00652A-(cit4d)/*[position()=1]
  publication-title: Org. Chem. Front.
  doi: 10.1039/D0QO00145G
– volume: 14
  start-page: 2091
  year: 2012
  ident: D0GC00652A-(cit7b)/*[position()=1]
  publication-title: Green Chem.
  doi: 10.1039/c2gc35635j
– volume: 59
  start-page: 8463
  year: 2003
  ident: D0GC00652A-(cit12b)/*[position()=1]
  publication-title: Tetrahedron
  doi: 10.1016/S0040-4020(03)01201-8
– volume: 46
  start-page: 1295
  year: 2017
  ident: D0GC00652A-(cit1a)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/C6CS00444J
– volume: 22
  start-page: 16684
  year: 2016
  ident: D0GC00652A-(cit9f)/*[position()=1]
  publication-title: Chem. – Eur. J.
  doi: 10.1002/chem.201603412
– volume: 16
  start-page: 1168
  year: 2014
  ident: D0GC00652A-(cit5c)/*[position()=1]
  publication-title: Green Chem.
  doi: 10.1039/c3gc42130a
– volume: 15
  start-page: 566
  year: 2013
  ident: D0GC00652A-(cit9e)/*[position()=1]
  publication-title: Org. Lett.
  doi: 10.1021/ol3033829
– volume: 26
  start-page: 1799
  year: 2002
  ident: D0GC00652A-(cit11c)/*[position()=1]
  publication-title: New J. Chem.
  doi: 10.1039/b205800f
– volume: 38
  start-page: 2472
  year: 1995
  ident: D0GC00652A-(cit11d)/*[position()=1]
  publication-title: J. Med. Chem.
  doi: 10.1021/jm00013a023
– volume: 126
  start-page: 6870
  year: 2004
  ident: D0GC00652A-(cit13b)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja031770o
– volume: 17
  start-page: 2983
  year: 2009
  ident: D0GC00652A-(cit10)/*[position()=1]
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2009.03.020
– volume: 3
  start-page: 1189
  year: 2012
  ident: D0GC00652A-(cit1b)/*[position()=1]
  publication-title: Med. Chem. Commun.
  doi: 10.1039/c2md20089a
– volume: 1
  start-page: 8
  year: 1962
  ident: D0GC00652A-(cit9a)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed. Engl.
  doi: 10.1002/anie.196200081
– volume: 18
  start-page: 310
  year: 2001
  ident: D0GC00652A-(cit11b)/*[position()=1]
  publication-title: Nat. Prod. Rep.
  doi: 10.1039/b006257j
– volume: 15
  start-page: 44353
  year: 2015
  ident: D0GC00652A-(cit5b)/*[position()=1]
  publication-title: RSC Adv.
  doi: 10.1039/C5RA06747B
– start-page: 1133
  year: 2003
  ident: D0GC00652A-(cit1d)/*[position()=1]
  publication-title: Eur. J. Org. Chem.
  doi: 10.1002/ejoc.200390167
– volume: 22
  start-page: 7837
  year: 2016
  ident: D0GC00652A-(cit2c)/*[position()=1]
  publication-title: Chem. – Eur. J.
  doi: 10.1002/chem.201600285
– volume: 11
  start-page: 1555
  year: 2009
  ident: D0GC00652A-(cit4c)/*[position()=1]
  publication-title: Org. Lett.
  doi: 10.1021/ol9001619
– volume: 74
  start-page: 1019
  year: 2009
  ident: D0GC00652A-(cit13c)/*[position()=1]
  publication-title: J. Org. Chem.
  doi: 10.1021/jo802016t
– volume: 114
  start-page: 8323
  year: 2014
  ident: D0GC00652A-(cit2f)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/cr400615v
– volume: 133
  start-page: 14804
  year: 2011
  ident: D0GC00652A-(cit12a)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja205891m
– volume: 18
  start-page: 5038
  year: 2016
  ident: D0GC00652A-(cit6)/*[position()=1]
  publication-title: Org. Lett.
  doi: 10.1021/acs.orglett.6b02493
– volume: 71
  start-page: 373
  year: 1959
  ident: D0GC00652A-(cit8)/*[position()=1]
  publication-title: Angew. Chem.
– volume: 47
  start-page: 3622
  year: 2008
  ident: D0GC00652A-(cit9d)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.200800494
– volume: 5
  start-page: 78572
  year: 2015
  ident: D0GC00652A-(cit11e)/*[position()=1]
  publication-title: RSC Adv.
  doi: 10.1039/C5RA14988F
– volume: 21
  start-page: 19
  year: 2016
  ident: D0GC00652A-(cit3)/*[position()=1]
  publication-title: Molecules
  doi: 10.3390/molecules21010019
– volume: 16
  start-page: 6310
  year: 2010
  ident: D0GC00652A-(cit13e)/*[position()=1]
  publication-title: Chem. – Eur. J.
  doi: 10.1002/chem.201000046
– volume: 139
  start-page: 888
  year: 2017
  ident: D0GC00652A-(cit14b)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.6b11188
– volume: 112
  start-page: 3083
  year: 2012
  ident: D0GC00652A-(cit2e)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/cr100233r
– volume: 112
  start-page: 3083
  year: 2012
  ident: WOS:000305108600002
  article-title: Chemistry and Biology Of Multicomponent Reactions
  publication-title: CHEMICAL REVIEWS
  doi: 10.1021/cr100233r
– volume: 82
  start-page: 12590
  year: 2017
  ident: WOS:000417342300061
  article-title: Unconventional Method for Synthesis of 3-Carboxyethyl-4-formyl(hydroxy)-5-aryl-N-arylpyrazoles
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
  doi: 10.1021/acs.joc.7b02361
– volume: 37
  start-page: 2234
  year: 1998
  ident: WOS:000075860500016
  article-title: A new heterocyclic multicomponent reaction for the combinatorial synthesis of fused 3-aminoimidazoles
  publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
– volume: 133
  start-page: 14804
  year: 2011
  ident: WOS:000295148100053
  article-title: Chiral Phosphoric Acid-Catalyzed Enantioselective Three-Component Povarov Reaction Using Enecarbamates as Dienophiles: Highly Diastereo- and Enantioselective Synthesis of Substituted 4-Aminotetrahydroquinolines
  publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  doi: 10.1021/ja205891m
– volume: 42
  start-page: 4948
  year: 2013
  ident: WOS:000319527400008
  article-title: Higher-order multicomponent reactions: beyond four reactants
  publication-title: CHEMICAL SOCIETY REVIEWS
  doi: 10.1039/c3cs35505e
– volume: 59
  start-page: 8463
  year: 2003
  ident: WOS:000186109100001
  article-title: Recent developments in the chemistry of enaminones
  publication-title: TETRAHEDRON
  doi: 10.1016/S0040-4020(03)01201-8
– volume: 139
  start-page: 888
  year: 2017
  ident: WOS:000392459300050
  article-title: Diverse ortho-C(sp(2))-H Functionalization of Benzaldehydes Using Transient Directing Groups
  publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  doi: 10.1021/jacs.6b11188
– volume: 74
  start-page: 1019
  year: 2009
  ident: WOS:000263004300008
  article-title: Synthesis and C-Alkylation of Hindered Aldehyde Enamines
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
  doi: 10.1021/jo802016t
– volume: 5
  start-page: 78572
  year: 2015
  ident: WOS:000361675800023
  article-title: Navigating in chromone chemical space: discovery of novel and distinct A(3) adenosine receptor ligands
  publication-title: RSC ADVANCES
  doi: 10.1039/c5ra14988f
– volume: 115
  start-page: 9028
  year: 2015
  ident: WOS:000361254500004
  article-title: Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity
  publication-title: CHEMICAL REVIEWS
  doi: 10.1021/cr500691k
– volume: 2003
  start-page: 1133
  year: 2003
  ident: WOS:000182125100001
  article-title: Recent developments in the isonitrile-based multicomponent synthesis of heterocycles
  publication-title: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
– volume: 11
  start-page: 1555
  year: 2009
  ident: WOS:000264622600024
  article-title: Synthesis of Pyrroles by Consecutive Multicomponent Reaction/[4+1] Cycloaddition of alpha-Iminonitriles with Isocyanides
  publication-title: ORGANIC LETTERS
  doi: 10.1021/ol9001619
– volume: 15
  start-page: 566
  year: 2013
  ident: WOS:000314559000036
  article-title: Model Studies on the First Enzyme-Catalyzed Ugi Reaction
  publication-title: ORGANIC LETTERS
  doi: 10.1021/ol3033829
– volume: 18
  start-page: 631
  year: 2016
  ident: WOS:000370768200001
  article-title: An Ugi Reaction Incorporating a Redox-Neutral Amine C-H Functionalization Step
  publication-title: ORGANIC LETTERS
  doi: 10.1021/acs.orglett.5b03529
– volume: 5
  start-page: 57883
  year: 2015
  ident: WOS:000357805500077
  article-title: Recent advances in multicomponent reactions involving carbohydrates
  publication-title: RSC ADVANCES
  doi: 10.1039/c5ra08059b
– volume: 22
  start-page: 7837
  year: 2016
  ident: WOS:000380267100024
  article-title: Trityl Isocyanide as a Mechanistic Probe in Multicomponent Chemistry: Walking the Line between Ugi- and Strecker-type Reactions
  publication-title: CHEMISTRY-A EUROPEAN JOURNAL
  doi: 10.1002/chem.201600285
– volume: 21
  year: 2016
  ident: WOS:000369485600008
  article-title: Isocyanide-Based Multicomponent Reactions for the Synthesis of Heterocycles
  publication-title: MOLECULES
  doi: 10.3390/molecules21010019
– volume: 17
  start-page: 2983
  year: 2009
  ident: WOS:000265044500004
  article-title: Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
  doi: 10.1016/j.bmc.2009.03.020
– volume: 9
  start-page: 449
  year: 2007
  ident: WOS:000243706400018
  article-title: Direct synthesis of pyrroles from imines, alkynes, and acid chlorides: An isocyanide-mediated reaction
  publication-title: ORGANIC LETTERS
  doi: 10.1021/ol062773j
– volume: 351
  start-page: 252
  year: 2016
  ident: WOS:000368098600035
  article-title: Functionalization of C(sp(3))-H bonds using a transient directing group
  publication-title: SCIENCE
  doi: 10.1126/science.aad7893
– volume: 5
  start-page: 44353
  year: 2015
  ident: WOS:000354964900055
  article-title: The first catalyst and solvent-free synthesis of 2-arylimidazo[2,1-b][1,3,4]thiadiazoles: a comparative assessment of greenness
  publication-title: RSC ADVANCES
  doi: 10.1039/c5ra06747b
– volume: 26
  start-page: 1799
  year: 2002
  ident: WOS:000179340500017
  article-title: A new series of 2-substituted 3-phosphonic derivatives of chromone. Part II. Synthesis, in vitro alkylating and in vivo antitumour activity
  publication-title: NEW JOURNAL OF CHEMISTRY
  doi: 10.1039/b205800f
– volume: 3
  start-page: 465
  year: 1986
  ident: WOS:A1986F560400004
  article-title: CHROMANOLS, CHROMANONES, AND CHROMONES
  publication-title: NATURAL PRODUCT REPORTS
– volume: 3
  start-page: 1189
  year: 2012
  ident: WOS:000310423600001
  article-title: Recent applications of multicomponent reactions in medicinal chemistry
  publication-title: MEDCHEMCOMM
  doi: 10.1039/c2md20089a
– volume: 16
  start-page: 6310
  year: 2010
  ident: WOS:000278880300023
  article-title: Transition States and Origins of 1,4-Asymmetric Induction in Alkylations of 2,2,6-Trialkylpiperidine Enamines
  publication-title: CHEMISTRY-A EUROPEAN JOURNAL
  doi: 10.1002/chem.201000046
– volume: 46
  start-page: 1295
  year: 2017
  ident: WOS:000396134400004
  article-title: To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis
  publication-title: CHEMICAL SOCIETY REVIEWS
  doi: 10.1039/c6cs00444j
– volume: 3
  start-page: 4610
  year: 2013
  ident: WOS:000315905400022
  article-title: Boric acid catalyzed Ugi three-component reaction in aqueous media
  publication-title: RSC ADVANCES
  doi: 10.1039/c3ra23087b
– volume: 25
  start-page: 2547
  year: 2016
  ident: WOS:000386763500011
  article-title: Synthesis and evaluation of chromone-2-carboxamide derivatives as cytotoxic agents and 5-lipoxygenase inhibitors
  publication-title: MEDICINAL CHEMISTRY RESEARCH
  doi: 10.1007/s00044-016-1691-y
– volume: 7
  start-page: 987
  year: 2020
  ident: WOS:000526910600002
  article-title: Expeditious access of chromone analogues via a Michael addition-driven multicomponent reaction
  publication-title: ORGANIC CHEMISTRY FRONTIERS
  doi: 10.1039/d0qo00145g
– volume: 22
  start-page: 16684
  year: 2016
  ident: 000544314300003.9
  publication-title: Chem. - Eur. J.
– volume: 14
  start-page: 2091
  year: 2012
  ident: WOS:000306658200002
  article-title: Multicomponent reactions in unconventional solvents: state of the art
  publication-title: GREEN CHEMISTRY
  doi: 10.1039/c2gc35635j
– volume: 16
  start-page: 1168
  year: 2014
  ident: WOS:000332039200025
  article-title: A facile protocol for the synthesis of 3-aminoimidazo-fused heterocycles via the Groebke-Blackburn-Bienayme reaction under catalyst-free and solvent-free conditions
  publication-title: GREEN CHEMISTRY
  doi: 10.1039/c3gc42130a
– volume: 670
  start-page: 74
  year: 1963
  ident: WOS:A19634479A00022
  article-title: ISONITRILE .16. MIT O-+C-ACYL-WANDERUNG GEKOPPELTE ALPHA-ADDITIONEN VON N-ALKYLCHINOLINIUM- UND CARBOXYLAT-IONEN DER ISONITRILE
  publication-title: ANNALEN DER CHEMIE-JUSTUS LIEBIG
– volume: 35
  start-page: 68
  year: 2006
  ident: WOS:000234096200006
  article-title: Organic chemistry in water
  publication-title: CHEMICAL SOCIETY REVIEWS
  doi: 10.1039/b507207g
– volume: 74
  start-page: 9
  year: 1962
  ident: WOS:A19624242A00074
  article-title: NEUERE METHODEN DER PRAPARATIVEN ORGANISCHEN CHEMIE .4. MIT SEKUNDAR-REAKTIONEN GEKOPPELTE ALPHA-ADDITIONEN VON IMMONIUM-IONEN UND ANIONEN AN ISONITRILE
  publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
– volume: 126
  start-page: 6870
  year: 2004
  ident: WOS:000221828200017
  article-title: Enamines from terminal epoxides and hindered lithium amides
  publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  doi: 10.1021/ja031770o
– volume: 47
  start-page: 3622
  year: 2008
  ident: WOS:000255530100031
  article-title: Catalytic three-component Ugi reaction
  publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
  doi: 10.1002/anie.200800494
– volume: 39
  start-page: 3168
  year: 2000
  ident: WOS:000089433600001
  article-title: Multicomponent reactions with isocyanides
  publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
– start-page: 1875
  year: 2018
  ident: 000544314300003.42
  publication-title: Synthesis
– volume: 114
  start-page: 8323
  year: 2014
  ident: WOS:000340992200013
  article-title: Small Heterocycles in Multicomponent Reactions
  publication-title: CHEMICAL REVIEWS
  doi: 10.1021/cr400615v
– volume: 38
  start-page: 2472
  year: 1995
  ident: WOS:A1995RF52600023
  article-title: (PIPERIDINYLALKOXY)CHROMONES - NOVEL ANTIHISTAMINES WITH ADDITIONAL ANTAGONISTIC ACTIVITY AGAINST LEUKOTRIENE D-4
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
– volume: 71
  start-page: 386
  year: 1959
  ident: WOS:A1959WY43600066
  article-title: VERSUCHE MIT ISONITRILEN
  publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
– volume: 18
  start-page: 310
  year: 2001
  ident: WOS:000169554300004
  article-title: Anthocyanins and other flavonoids
  publication-title: NATURAL PRODUCT REPORTS
  doi: 10.1039/b006257j
– volume: 22
  start-page: 503
  year: 2018
  ident: WOS:000434996100014
  article-title: Recent advances in the development of polycyclic skeletons via Ugi reaction cascades
  publication-title: MOLECULAR DIVERSITY
  doi: 10.1007/s11030-017-9811-2
– volume: 21
  start-page: 6051
  year: 2019
  ident: WOS:000496489100002
  article-title: Visible-light-mediated metal-free decarboxylative acylations of isocyanides with alpha-oxocarboxylic acids and water leading to alpha-ketoamides
  publication-title: GREEN CHEMISTRY
  doi: 10.1039/c9gc03253c
– volume: 18
  start-page: 5038
  year: 2016
  ident: WOS:000385053900072
  article-title: 1,4-Addition Ugi Reaction Using Cyclic alpha,beta-Unsaturated Ketone as Substrate
  publication-title: ORGANIC LETTERS
  doi: 10.1021/acs.orglett.6b02493
SSID ssj0011764
Score 2.4710796
SecondaryResourceType review_article
Snippet A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol...
A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanonesviaa facile, mild, and efficient one-pot protocol without...
A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol...
Source Web of Science
SourceID proquest
webofscience
crossref
SourceType Aggregation Database
Enrichment Source
Index Database
StartPage 3716
SubjectTerms Alkenes
Catalysts
catalytic activity
Chemical synthesis
Chemistry
Chemistry, Multidisciplinary
Crystallography
Green & Sustainable Science & Technology
Green chemistry
hydrogen bonding
Hydrogen bonds
Imines
Physical Sciences
schiff bases
Science & Technology
Science & Technology - Other Topics
Title An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water
URI http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000544314300003
https://www.proquest.com/docview/2415408689
https://www.proquest.com/docview/2477616739
Volume 22
WOS 000544314300003
WOSCitedRecordID wos000544314300003
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Rb9MwELZK9wA8IChMFAYKYi-oBBI7iZfHqus2pjJeUqk8RY7tTJVQirZWaPtD_E3uHDtJpwoNXqLWucRJ7uL77vzlTMhhUFKlZRj7KoC3KdIQp6RYCBL-CcHCMgg15ju-XiRn8-h8ES96vd8d1tJmXXyStzu_K_kfrUIb6BW_kv0HzTYnhQb4DfqFLWgYtvfS8bgaCblUvsnB3NwCdoRxaRL5SBKqSYzw7G9EtVTaR3elav4g0shXFZIAADFKx3asMFfwSzi6rgWshpczkm5ZOJNBEJWpMtEmEl35CUzCX9454MrOD5gjT9tCj9rQCM6XjWHNTMP3lXWl0LLY1CKN5zgGW_ZRYpQJK2YTFhTXtfFpG97WaRHHSTWcE3tFnWE4SpiPlQxrL9Vtq5cZcWM3pV0bpZ2RmPEw6Xh1XIxnp8cIGBZcVcGlRDRGO37RcQEuvuUn89ksz6aL7AHZoxCP0D7ZG0-zL7NmwirkplJZc-GuEi5LP7fn3sY-bUCzA_IYeJM9JU9sXOKNayN7Rnq6GpCHzUMbkMedypUDsj9tP5CEw6yHuH5O5uPK27ZJL_zYWqR31yK9bYv0nEV6y8pDi_SMRb4g85NpNjnz7dIdvmQ0XfuqSKSQMmachyUE9UUEgTJgTS7SkjLGY9gVMFXqsEgxJklFHPGCR7RMZXSkS7ZP-hX0-5J4VCVMxpxzLQFOqjJVRcl1rABoYkM6JB_cQ82lrWuPy6v8yA2_gqX5cXA6MQoYD8n7RvZnXc1lp9SB001uX6DrHJFuBPH_EXT4rtkNOsAJNlHp1QZlOE_ChDOQOezqtOnMhEiA2SOGQJENSXgfsYm9LSxTsX7196t7TR61L90B6a-vNvoN4OZ18dba7B_JzsSN
linkProvider Royal Society of Chemistry
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=An+acid-catalyzed+1%2C4-addition+isocyanide-based+multicomponent+reaction+in+neat+water&rft.jtitle=Green+chemistry+%3A+an+international+journal+and+green+chemistry+resource+%3A+GC&rft.au=Lei%2C+Jie&rft.au=Li%2C+Yong&rft.au=Xu%2C+Jia&rft.au=Dian-Yong+Tang&rft.date=2020-06-22&rft.pub=Royal+Society+of+Chemistry&rft.issn=1463-9262&rft.eissn=1463-9270&rft.volume=22&rft.issue=12&rft.spage=3716&rft.epage=3720&rft_id=info:doi/10.1039%2Fd0gc00652a&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1463-9262&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1463-9262&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1463-9262&client=summon