Genome‐wide gene‐environment interaction in depression: A systematic evaluation of candidate genes The childhood trauma working‐group of PGC‐MDD

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 177; no. 1; pp. 40 - 49
• Main Authors: Van der Auwera, Sandra, Peyrot, Wouter J., Milaneschi, Yuri, Hertel, Johannes, Baune, Bernhard, Breen, Gerome, Byrne, Enda, Dunn, Erin C., Fisher, Helen, Homuth, Georg, Levinson, Douglas, Lewis, Cathryn, Mills, Natalie, Mullins, Niamh, Nauck, Matthias, Pistis, Giorgio, Preisig, Martin, Rietschel, Marcella, Ripke, Stephan, Sullivan, Patrick, Teumer, Alexander, Völzke, Henry, Boomsma, Dorret I., Wray, Naomi R., Penninx, Brenda, Grabe, Hans
• Format: Journal Article
• Language: English
• Published: United States 01.01.2018
• Subjects: Case-Control Studies; Depression - etiology; Depression - genetics; Depressive Disorder, Major - etiology; Depressive Disorder, Major - genetics; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genome-Wide Association Study - methods; Humans; Life Change Events; Male; Polymorphism, Single Nucleotide - genetics; Risk Factors; White People - genetics; GWAS; depression; candidate genes; Psychiatric Genomics Consortium

Gene by environment (GxE) interaction studies have investigated the influence of a number of candidate genes and variants for major depressive disorder (MDD) on the association between childhood trauma and MDD. Most of these studies are hypothesis driven and investigate only a limited number of SNPs...