eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer

• Published in: Science signaling Vol. 17; no. 826; p. eadh4475
• Main Authors: Treekitkarnmongkol, Warapen, Solis, Luisa M, Sankaran, Deivendran, Gagea, Mihai, Singh, Pankaj K, Mistry, Ragini, Nguyen, Tristian, Kai, Kazuharu, Liu, Jiajun, Sasai, Kaori, Jitsumori, Yoshimi, Liu, Jianwen, Nagao, Norio, Stossi, Fabio, Mancini, Michael A, Wistuba, Ignacio I, Thompson, Alastair M, Lee, Jonathan M, Cadiñanos, Juan, Wong, Kwong-Kwok, Abbott, Catherine M, Sahin, Aysegul A, Liu, Suyu, Katayama, Hiroshi, Sen, Subrata
• Format: Journal Article
• Language: English
• Published: United States 05.03.2024
• Subjects: Animals; Aurora Kinase A - genetics; Aurora Kinase A - metabolism; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; F-Box-WD Repeat-Containing Protein 7 - genetics; Female; Glycogen Synthase Kinase 3 beta; Humans; Mammary Neoplasms, Animal - genetics; Mammary Neoplasms, Animal - metabolism; Mammary Neoplasms, Animal - pathology; Mice; Peptide Elongation Factor 1 - genetics; Peptide Elongation Factor 1 - metabolism; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism

The translation elongation factor eEF1A promotes protein synthesis. Its methylation by METTL13 increases its activity, supporting tumor growth. However, in some cancers, a high abundance of eEF1A isoforms is associated with a good prognosis. Here, we found that eEF1A2 exhibited oncogenic or tumor-su...