Genetic regulation, biochemical properties and physiological importance of arginase from Sinorhizobium meliloti

• Published in: Microbiology (Society for General Microbiology) Vol. 166; no. 5; pp. 484 - 497
• Main Authors: Ide, Alejandra Arteaga, Hernández, Victor M, Medina-Aparicio, Liliana, Carcamo-Noriega, Edson, Girard, Lourdes, Hernández-Lucas, Ismael, Dunn, Michael F
• Format: Journal Article
• Language: English
• Published: England 01.05.2020
• Subjects: Arginase - genetics; Arginase - physiology; Arginine - metabolism; Bacterial Proteins - genetics; Bacterial Proteins - physiology; Gene Expression Regulation; Genetic Complementation Test; Genome, Bacterial; Hydrogen-Ion Concentration; Mutation; Nitrogen - metabolism; Ornithine - metabolism; Recombinant Proteins; Sinorhizobium meliloti - enzymology; Sinorhizobium meliloti - genetics; Sinorhizobium meliloti - physiology; Urea - metabolism; L-ornithine; divalent metal cofactor; Lrp family regulator; L-arginine; arginase

In bacteria, l-arginine is a precursor of various metabolites and can serve as a source of carbon and/or nitrogen. Arginine catabolism by arginase, which hydrolyzes arginine to l-ornithine and urea, is common in nature but has not been studied in symbiotic nitrogen-fixing rhizobia. The genome of the...