Roles of catalase and the glutathione redox cycle in the regulation of anterior-chamber hydrogen peroxide

• Published in: Ophthalmic research Vol. 23; no. 5; p. 284
• Main Authors: Costarides, A P, Riley, M V, Green, K
• Format: Journal Article
• Language: English
• Published: Switzerland 1991
• Subjects: Amitrole - pharmacology; Animals; Anterior Chamber - metabolism; Anterior Eye Segment - metabolism; Antimetabolites - pharmacology; Aqueous Humor - metabolism; Ascorbic Acid - metabolism; Buthionine Sulfoximine; Carmustine - pharmacology; Catalase - antagonists & inhibitors; Catalase - physiology; Glutathione - antagonists & inhibitors; Glutathione - metabolism; Glutathione Reductase - antagonists & inhibitors; Glutathione Reductase - metabolism; Hydrogen Peroxide - metabolism; Methionine Sulfoximine - analogs & derivatives; Methionine Sulfoximine - pharmacology; Oxidation-Reduction; Rabbits

The effects of inhibition of both glutathione synthesis and of glutathione reductase and catalase activities have been determined in the regulation of hydrogen peroxide (H2O2) in the anterior chamber of pigmented rabbits. Glutathione reductase inhibition using intravitreal 1,3-bis-(2-chloroethyl)-1-...