Multiple Sclerosis: Effects of Cognitive Rehabilitation on Structural and Functional MR Imaging Measures—An Explorative Study

• Published in: Radiology Vol. 262; no. 3; pp. 932 - 940
• Main Authors: Filippi, Massimo, Riccitelli, Gianna, Mattioli, Flavia, Capra, Ruggero, Stampatori, Chiara, Pagani, Elisabetta, Valsasina, Paola, Copetti, Massimiliano, Falini, Andrea, Comi, Giancarlo, Rocca, Maria A.
• Format: Journal Article
• Language: English
• Published: United States 01.03.2012
• Subjects: Adult; Attention; Brain; Brain - pathology; Brain - physiopathology; Cingulum; Cognition Disorders - pathology; Cognition Disorders - physiopathology; Cognition Disorders - rehabilitation; Cognitive ability; Cortex (cingulate); Cortex (parietal); Cortex (prefrontal); Echo-Planar Imaging; Executive function; Female; Functional magnetic resonance imaging; Humans; Information processing; Linear Models; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Middle Aged; Multiple sclerosis; Multiple Sclerosis - pathology; Multiple Sclerosis - physiopathology; Multiple Sclerosis - rehabilitation; Neuropsychological Tests; Recruitment; Rehabilitation; Statistics, Nonparametric; Structure-function relationships; Substantia alba; Substantia grisea; Treatment Outcome

To evaluate brain changes after cognitive rehabilitation in patients with clinically stable relapsing-remitting (RR) multiple sclerosis (MS) by using neuropsychologic assessment and structural and functional magnetic resonance (MR) imaging techniques. The study was conducted with approval of the inv...