Both protein and non-protein components in extracellular vesicles of human seminal plasma improve human sperm function via CatSper-mediated calcium signaling

• Published in: Human reproduction (Oxford) Vol. 39; no. 4; pp. 658 - 673
• Main Authors: Zhang, Xiaoning, Liang, Min, Song, Dandan, Huang, Rongzu, Chen, Chen, Liu, Xiaojun, Chen, Houyang, Wang, Qingxin, Sun, Xiaoli, Song, Jian, Zhang, Jiali, Kang, Hang, Zeng, Xuhui
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 03.04.2024
• Subjects: Asthenozoospermia - metabolism; Calcium - metabolism; Calcium Channels - metabolism; Calcium Signaling; Extracellular Vesicles - chemistry; Extracellular Vesicles - metabolism; Humans; Male; Peptides - metabolism; Peptides - pharmacology; Semen - chemistry; Semen - metabolism; Sperm Motility - physiology; Spermatozoa - metabolism; hyperactivation; CatSper; sperm function; seminal plasma extracellular vesicles; asthenozoospermia; calcium signal

Abstract STUDY QUESTION What is the significance and mechanism of human seminal plasma extracellular vesicles (EVs) in regulating human sperm functions? SUMMARY ANSWER EV increases the intracellular Ca2+ concentrations [Ca2+]i via extracellular Ca2+ influx by activating CatSper channels, and subsequ...