Effects of administration of cationic and native homologous albumin on the kidney

• Published in: Nephron (2015) Vol. 33; no. 3; p. 208
• Main Authors: Coimbra, T M, Furtado, M R, Lachat, J J, de Carvalho, I F
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.1983
• Subjects: Albumins - administration & dosage; Albumins - pharmacology; Animals; Anions; Cations; Chemical Phenomena; Chemistry; Creatinine - urine; Female; Kidney - drug effects; Kidney - pathology; Kidney - ultrastructure; Kidney Glomerulus - drug effects; Kidney Glomerulus - pathology; Kidney Tubules, Proximal - drug effects; Kidney Tubules, Proximal - ultrastructure; Lysosomes - physiopathology; Microscopy, Electron; Proteinuria - chemically induced; Rats; Rats, Inbred Strains

Different doses of anionic and cationic albumin (CA) were administered intravenously to 29 normal unanesthetized female rats. Administration of 20 and 30 mg of CA produced an increase in urinary excretion of endogenous albumin. Urinary CA levels in the urine samples collected during the first 60 min...