Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 32; no. 2; pp. 286 - 297
• Main Authors: Li, Zhenshu, Zhou, Dezheng, Zhang, Dalong, Zhao, Jing, Li, Wen, Sun, Yue, Chen, Yongjie, Liu, Huan, Wilson, John X, Qian, Zhiyong, Huang, Guowei
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 10.01.2022
• Subjects: Aging; Animals; Apoptosis; Astrocytes; Folic Acid - pharmacology; Mice; Telomere; apoptosis; aging; telomere attrition; folic acid; astrocyte

Abstract Folic acid (FA) has been reported to inhibit astrocyte apoptosis and improve aging-induced disorders; however, its role in telomere attrition remains unclear. In present study, 4-month-old senescence-accelerated mouse prone 8 (SAMP8) mice were assigned to four treatment groups for the in vi...