Isolation, identification, and characterization of clones encoding antigens responsible for peanut hypersensitivity

• Published in: International archives of allergy and immunology Vol. 107; no. 1-3; p. 248
• Main Authors: Burks, A W, Cockrell, G, Stanley, J S, Helm, R M, Bannon, G A
• Format: Journal Article
• Language: English
• Published: Switzerland 01.05.1995
• Subjects: Allergens - chemistry; Allergens - genetics; Allergens - immunology; Allergens - isolation & purification; Antibody Specificity; Antigens, Plant; Arachis - genetics; Arachis - immunology; Base Sequence; DNA, Complementary - genetics; Escherichia coli; Food Hypersensitivity - immunology; Glycoproteins; Humans; Immunoglobulin E - immunology; Molecular Sequence Data; Plant Proteins - chemistry; Plant Proteins - genetics; Plant Proteins - immunology; Plant Proteins - isolation & purification; Recombinant Fusion Proteins - immunology; Seed Storage Proteins; Sequence Homology, Amino Acid

Peanut allergy is a significant health problem because of the frequency, the potential severity, and the chronicity of the allergic sensitivity. Serum IgE from patients with documented peanut hypersensitivity reactions and a peanut cDNA expression library were used to identify clones that encode pea...