Effects of L-arginine on preeclampsia risks and maternal and neonatal outcomes A systematic review and meta-analysis
Objective: To summarize whether the supplementation of L -arginine in pregnant women helps in management of preeclampsia and its impact on maternal and neonatal outcomes. Methods: Studies conducted from the past 17 years (1999 to 2016). were referred from database like Cochrane Central Registry of C...
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Published in | Asian Pacific Journal of Reproduction Vol. 10; no. 6; pp. 241 - 251 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Medknow Publications and Media Pvt. Ltd
01.11.2021
Wolters Kluwer Medknow Publications |
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Abstract | Objective: To summarize whether the supplementation of L -arginine in pregnant women helps in management of preeclampsia and its impact on maternal and neonatal outcomes. Methods: Studies conducted from the past 17 years (1999 to 2016). were referred from database like Cochrane Central Registry of Controlled Trials (CENTRAL), Scopus, Google Scholar and PubMed. Out of 134 studies, 7 studies were included. L -arginine versus placebo was considered for quantitative analysis. Modified Cochrane data extraction form was used to collect the data. The risk of bias was assessed using Cochrane's risk of bias assessment tool in RevMan 5.4 and the summary of findings was determined using GradePro software. Results: L -arginine showed a significant reduction of preeclampsia [odds ratio (OR) 0.38; 95% confidence interval (CI) 0.25, 0.58)]. There was a significant reduction in systolic blood pressure [mean difference (MD) -2.47; 95% CI -4.53, -0.42] and diastolic blood pressure (MD -0.97; 95% CI -3.83, 1.89). The effects of L -arginine on secondary outcomes like maternal gestational age, latency, neonatal weight, and appearance, pulse, grimace, activity, respiration (APGAR) score at 1st and 5th minute were not statistically significant. Conclusions: L -arginine supplementation is effective in lowering systolic and diastolic blood pressure of preeclamptic patients. However, it has no noticeable effects on maternal and neonatal outcomes. |
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AbstractList | Objective: To summarize whether the supplementation of L -arginine in pregnant women helps in management of preeclampsia and its impact on maternal and neonatal outcomes. Methods: Studies conducted from the past 17 years (1999 to 2016). were referred from database like Cochrane Central Registry of Controlled Trials (CENTRAL), Scopus, Google Scholar and PubMed. Out of 134 studies, 7 studies were included. L -arginine versus placebo was considered for quantitative analysis. Modified Cochrane data extraction form was used to collect the data. The risk of bias was assessed using Cochrane's risk of bias assessment tool in RevMan 5.4 and the summary of findings was determined using GradePro software. Results: L -arginine showed a significant reduction of preeclampsia [odds ratio (OR) 0.38; 95% confidence interval (CI) 0.25, 0.58)]. There was a significant reduction in systolic blood pressure [mean difference (MD) -2.47; 95% CI -4.53, -0.42] and diastolic blood pressure (MD -0.97; 95% CI -3.83, 1.89). The effects of L -arginine on secondary outcomes like maternal gestational age, latency, neonatal weight, and appearance, pulse, grimace, activity, respiration (APGAR) score at 1st and 5th minute were not statistically significant. Conclusions: L -arginine supplementation is effective in lowering systolic and diastolic blood pressure of preeclamptic patients. However, it has no noticeable effects on maternal and neonatal outcomes. |
Audience | Academic |
Author | Ramalingam, Gopi Hari, Oorvashree Sri Basutkar, Roopa Sagadevan, Shonitha Sirajudeen, Mohamed |
Author_xml | – sequence: 1 fullname: Sagadevan, Shonitha – sequence: 2 fullname: Hari, Oorvashree Sri – sequence: 3 fullname: Sirajudeen, Mohamed – sequence: 4 fullname: Ramalingam, Gopi – sequence: 5 fullname: Basutkar, Roopa |
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Cites_doi | 10.1097/00005344-199204002-00018 10.1111/j.1742-7843.2006.pto_468.x 10.1038/333664a0 10.1111/j.1365-2362.2005.01445.x 10.1111/1471-0528.12629 10.1016/j.ijgo.2006.10.011 10.3109/10641955.2015.1137586 10.1016/S0301-2115(03)00368-3 10.1016/S0928-4680(02)00052-4 10.3109/14767050903019650 10.1002/sim.1186 10.1080/10641950601147994 10.3109/10641959909009615 10.3109/14767051003677962 10.1136/bmj.d2901 10.1016/j.ijgo.2005.04.018 |
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References | Melamed (R23-1-20240901) 2009; 22 Leeman (R1-1-20240901) 2016; 93 Neri (R18-1-20240901) 2010; 23 Rytlewski (R19-1-20240901) 2006; 99 Vadillo-Ortega (R21-1-20240901) 2011; 342 Baksu (R8-1-20240901) 2005; 90 Palmer (R6-1-20240901) 1988; 333 Facchinetti (R17-1-20240901) 2007; 26 Abalos (R2-1-20240901) 2014; 121 Higgins (R14-1-20240901) 2002; 21 Chamy Picó (R12-1-20240901) 2006; 39 Facchinetti (R16-1-20240901) 1999; 6 Sibai (R3-1-20240901) 2003; 102 Serdar (R13-1-20240901) 2002; 9 Yallampalli (R9-1-20240901) 1994; 170 Vallance (R5-1-20240901) 1992; 20 Aydin (R7-1-20240901) 2004; 113 Rytlewski (R20-1-20240901) 2005; 35 Chamy Picó (R4-1-20240901) 2006; 39 Camarena Pulido (R15-1-20240901) 2016; 35 Neri (R10-1-20240901) 1999; 18 Biri (R11-1-20240901) 2007; 96 |
References_xml | – volume: 20 start-page: S60 year: 1992 ident: R5-1-20240901 article-title: Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis publication-title: J Cardiovasc Pharmacol doi: 10.1097/00005344-199204002-00018 contributor: fullname: Vallance – volume: 99 start-page: 146 year: 2006 ident: R19-1-20240901 article-title: Effects of oral L-arginine on the foetal condition and neonatal outcome in preeclampsia: A preliminary report publication-title: Basic Clin Pharmacol Toxicol doi: 10.1111/j.1742-7843.2006.pto_468.x contributor: fullname: Rytlewski – volume: 333 start-page: 664 year: 1988 ident: R6-1-20240901 article-title: Vascular endothelial cells synthesize nitric oxide from L-arginine publication-title: Nature doi: 10.1038/333664a0 contributor: fullname: Palmer – volume: 35 start-page: 32 year: 2005 ident: R20-1-20240901 article-title: Effects of prolonged oral supplementation with L-arginine on blood pressure and nitric oxide synthesis in preeclampsia publication-title: Eur J Clin Invest doi: 10.1111/j.1365-2362.2005.01445.x contributor: fullname: Rytlewski – volume: 121 start-page: 14 year: 2014 ident: R2-1-20240901 article-title: Preeclampsia, eclampsia and adverse maternal and perinatal outcomes: A secondary analysis of the World Health Organization Multicounty Survey on Maternal and New-born Health publication-title: BJOG doi: 10.1111/1471-0528.12629 contributor: fullname: Abalos – volume: 96 start-page: 196 year: 2007 ident: R11-1-20240901 article-title: Antioxidant enzyme activities and lipid peroxidation in preeclampsia publication-title: Int J Gynecol Obstet doi: 10.1016/j.ijgo.2006.10.011 contributor: fullname: Biri – volume: 35 start-page: 217 year: 2016 ident: R15-1-20240901 article-title: Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: A double-blind, randomized, clinical trial publication-title: Hypertens Pregnancy doi: 10.3109/10641955.2015.1137586 contributor: fullname: Camarena Pulido – volume: 113 start-page: 21 year: 2004 ident: R7-1-20240901 article-title: Plasma malondialdehyde, superoxide dismutase, sE-selectin, fibronectin, endothelin-1 and nitric oxide levels in women with preeclampsia publication-title: Eur J Obstet Gynecol Reprod Biol doi: 10.1016/S0301-2115(03)00368-3 contributor: fullname: Aydin – volume: 39 start-page: 229 year: 2006 ident: R12-1-20240901 article-title: Oxidative stress is closely related to clinical severity of preeclampsia publication-title: Biol Res contributor: fullname: Chamy Picó – volume: 9 start-page: 21 year: 2002 ident: R13-1-20240901 article-title: Placental and decidual lipid peroxidation and antioxidant defenses in preeclampsia -Lipid peroxidation in preeclampsia publication-title: Pathophysiology doi: 10.1016/S0928-4680(02)00052-4 contributor: fullname: Serdar – volume: 22 start-page: 1051 year: 2009 ident: R23-1-20240901 article-title: Factors affecting the duration of the latency period in preterm premature rupture of membranes publication-title: J Matern Fetal Neonatal Med doi: 10.3109/14767050903019650 contributor: fullname: Melamed – volume: 102 start-page: 181 year: 2003 ident: R3-1-20240901 article-title: Diagnosis and management of gestational hypertension and preeclampsia publication-title: Obstet Gynecol contributor: fullname: Sibai – volume: 21 start-page: 1539 year: 2002 ident: R14-1-20240901 article-title: Quantifying heterogeneity in a meta- analysis publication-title: Stat Med doi: 10.1002/sim.1186 contributor: fullname: Higgins – volume: 26 start-page: 121 year: 2007 ident: R17-1-20240901 article-title: L-arginine supplementation in patients with gestational hypertension: A pilot study publication-title: Hypertens Pregnancy doi: 10.1080/10641950601147994 contributor: fullname: Facchinetti – volume: 93 start-page: 121 year: 2016 ident: R1-1-20240901 article-title: Hypertensive disorders of pregnancy publication-title: Am Fam Phys contributor: fullname: Leeman – volume: 170 start-page: 175 year: 1994 ident: R9-1-20240901 article-title: An L-arginine-nitric oxide-cyclic guanosine monophosphate system exists in the uterus and inhibits contractility during pregnancy publication-title: Am J Obstet Gynecol contributor: fullname: Yallampalli – volume: 18 start-page: 107 year: 1999 ident: R10-1-20240901 article-title: 24-hour ambulatory blood pressure monitoring: A comparison between transdermal glyceryl-trinitrate and oral nifedipine publication-title: Hypertens Pregnancy doi: 10.3109/10641959909009615 contributor: fullname: Neri – volume: 23 start-page: 1456 year: 2010 ident: R18-1-20240901 article-title: L-arginine supplementation in women with chronic hypertension: Impact on blood pressure and maternal and neonatal complications publication-title: J Matern Neonatal Med doi: 10.3109/14767051003677962 contributor: fullname: Neri – volume: 342 start-page: 1 year: 2011 ident: R21-1-20240901 article-title: Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high-risk population: Randomised controlled trial publication-title: BMJ doi: 10.1136/bmj.d2901 contributor: fullname: Vadillo-Ortega – volume: 39 start-page: 229 year: 2006 ident: R4-1-20240901 article-title: Oxidative stress is closely related to clinical severity of pre-eclampsia publication-title: Biol Res contributor: fullname: Chamy Picó – volume: 90 start-page: 112 year: 2005 ident: R8-1-20240901 article-title: Plasma nitric oxide, endothelin-1 and urinary nitric oxide and cyclic guanosine monophosphate levels in hypertensive pregnant women publication-title: Int J Gynecol Obstet doi: 10.1016/j.ijgo.2005.04.018 contributor: fullname: Baksu – volume: 6 start-page: 202 year: 1999 ident: R16-1-20240901 article-title: L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release publication-title: J Soc Gynecol Investig contributor: fullname: Facchinetti |
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Snippet | Objective: To summarize whether the supplementation of L -arginine in pregnant women helps in management of preeclampsia and its impact on maternal and... Objective: To summarize whether the supplementation of L-arginine in pregnant women helps in management of preeclampsia and its impact on maternal and neonatal... |
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SubjectTerms | Arginine Infants (Newborn) l-arginine; amino acid supplementation; preeclampsia; pregnancy; arginine supplementation Preeclampsia Pregnant women |
Subtitle | A systematic review and meta-analysis |
Title | Effects of L-arginine on preeclampsia risks and maternal and neonatal outcomes |
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