GDF10 inhibits cell proliferation and epithelial–mesenchymal transition in nasopharyngeal carcinoma by the transforming growth factor-β/Smad and NF-κB pathways

• Published in: Carcinogenesis (New York) Vol. 43; no. 2; pp. 94 - 103
• Main Authors: He, Feng, Feng, Guofei, Ma, Ning, Midorikawa, Kaoru, Oikawa, Shinji, Kobayashi, Hatasu, Zhang, Zhe, Huang, Guangwu, Takeuchi, Kazuhiko, Murata, Mariko
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 24.03.2022
• Subjects: Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Epithelial-Mesenchymal Transition - genetics; Gene Expression Regulation, Neoplastic; Growth Differentiation Factor 10 - genetics; Humans; Nasopharyngeal Carcinoma - genetics; Nasopharyngeal Neoplasms - genetics; NF-kappa B - genetics; NF-kappa B - metabolism; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - metabolism

Abstract Growth differentiation factor-10 (GDF10) belongs to a member of the transforming growth factor-β (TGF-β) superfamily. Dysfunction of the TGF-β pathway can lead to carcinoma progression. Previous studies have shown that GDF10 acts as a tumor suppressor gene in some cancers. However, the mole...