α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson’s disease model

• Published in: Brain (London, England : 1878) Vol. 143; no. 1; pp. 249 - 265
• Main Authors: Taguchi, Tomoyuki, Ikuno, Masashi, Hondo, Mari, Parajuli, Laxmi Kumar, Taguchi, Katsutoshi, Ueda, Jun, Sawamura, Masanori, Okuda, Shinya, Nakanishi, Etsuro, Hara, Junko, Uemura, Norihito, Hatanaka, Yusuke, Ayaki, Takashi, Matsuzawa, Shuichi, Tanaka, Masaki, El-Agnaf, Omar M A, Koike, Masato, Yanagisawa, Masashi, Uemura, Maiko T, Yamakado, Hodaka, Takahashi, Ryosuke
• Format: Journal Article
• Language: English
• Published: England 01.01.2020
• Subjects: alpha-synuclein; RBD; prodromal PD; Parkinson’s disease; hyposmia

Parkinson’s disease is one of the most common movement disorders and is characterized by dopaminergic cell loss and the accumulation of pathological α-synuclein, but its precise pathogenetic mechanisms remain elusive. To develop disease-modifying therapies for Parkinson’s disease, an animal model th...