New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer

[Display omitted] •Design and synthesis of new 2,6,9-trisubstituted purine derivatives.•8f, 8g and 8h have IC50 values of 4.56, 4.11 and 3.08 μM on Mia-PaCa-2 cells, respectively.•8f and 8h bind to SMO with higher affinities that our previous SMO ligand.•8g was able to inhibit Hh pathway on lucifera...

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Bibliographic Details
Published inBioorganic chemistry Vol. 151; p. 107681
Main Authors Espinosa-Bustos, Christian, Bertrand, Jeanluc, Villegas-Menares, Alondra, Guerrero, Simón, Di Marcotullio, Lucia, Navacci, Shirin, Schulte, Gunnar, Kozielewicz, Pawel, Bloch, Nicolas, Villela, Valentina, Paulino, Margot, Kogan, Marcelo J., Cantero, Jorge, Salas, Cristian O.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2024
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