New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer
[Display omitted] •Design and synthesis of new 2,6,9-trisubstituted purine derivatives.•8f, 8g and 8h have IC50 values of 4.56, 4.11 and 3.08 μM on Mia-PaCa-2 cells, respectively.•8f and 8h bind to SMO with higher affinities that our previous SMO ligand.•8g was able to inhibit Hh pathway on lucifera...
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Published in | Bioorganic chemistry Vol. 151; p. 107681 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.10.2024
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Subjects | |
Online Access | Get full text |
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