Three new diterpenoids from Leonurus japonicus

Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid,leojaponin A（1）,characterized by a C4–C7oxa-bridge,and two new labdane diterpenoids,leojaponins B（2） and C（3）.The structures of these new compounds were determined based on...

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Published inChinese chemical letters Vol. 25; no. 5; pp. 677 - 679
Main Authors Liu, Zhi-Ke, Wu, Da-Rong, Shi, Yi-Ming, Zeng, Ting, Liu, Shao-Hua, Du, Xue, Dang, Yong-Jun, Xiao, Wei-Lie, Sun, Han-Dong
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.05.2014
Subjects
Leojaponin A
Leojaponin B
Leojaponin C
Leonurus japonicus
二维核磁共振
二萜类化合物
光谱数据
地上部分
新化合物
植物化学物质
益母草
细胞毒性
Leojaponin C
Leojaponin A
Leojaponin B
Leonurus japonicus
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Summary:Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid,leojaponin A（1）,characterized by a C4–C7oxa-bridge,and two new labdane diterpenoids,leojaponins B（2） and C（3）.The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic data.To the best of our knowledge,compound 1 is the first clerodane diterpenoid obtained from Leonurus.japonicus.All of them were evaluated for their cytotoxicity.
Bibliography:Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid,leojaponin A（1）,characterized by a C4–C7oxa-bridge,and two new labdane diterpenoids,leojaponins B（2） and C（3）.The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic data.To the best of our knowledge,compound 1 is the first clerodane diterpenoid obtained from Leonurus.japonicus.All of them were evaluated for their cytotoxicity.
11-2710/O6
Leonurus japonicus Leojaponin A Leojaponin B Leojaponin C
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2014.01.047