Iohexol clearance for renal function measurement in gynaecologic cancer patients

• Published in: Acta radiologica (1987) Vol. 37; no. 4; p. 582
• Main Authors: Lundqvist, S, Edbom, G, Groth, S, Stendahl, U, Hietala, S O
• Format: Journal Article
• Language: English
• Published: England 01.07.1996
• Subjects: Adult; Aged; Aged, 80 and over; Contrast Media; Creatinine - metabolism; Edetic Acid; Female; Genital Neoplasms, Female - diagnostic imaging; Genital Neoplasms, Female - physiopathology; Glomerular Filtration Rate; Humans; Iohexol; Middle Aged; Spectrometry, X-Ray Emission; Urography
• DOI: 10.3109/02841859609175449
• ISSN: 0284-1851

To determine a valid and practical routine for glomerular filtration rate measurement in gynaecologic cancer patients. The established method, endogenous creatinine clearance, was compared to 51Cr-EDTA clearance and contrast medium clearance in 68 women with various gynaecologic carcinomas. Contrast medium clearance was determined in association with conventional urography (iohexal 300 mg I/ml, 40 ml) for evaluation of urinary tract involvement by the tumour. Automated X-ray fluorescence analysis equipment was used for the plasma analysis of iohexol and clearance calculations. Endogenous creatinine clearance and 51Cr-EDTA clearance were determined according to standard routine procedures. Simultaneous determinations of contrast medium clearance and 51Cr-EDTA clearance (n = 33), contrast medium clearance and endogenous creatinine clearance (n = 50), as well as 51Cr-EDTA clearance and endogenous creatinine clearance (n = 30) were compared. The mean differences were -2.8 (SD 6.6), -1.8 (SD 22.3), and 2.7 (SD 18.3) ml/min/1.73 m2, respectively. It is concluded that contrast medium clearance is as adequate as 51Cr-EDTA clearance for glomerular filtration rate measurement. We suggest that contrast medium clearance should replace endogenous creatinine clearance, especially in patients referred for urography.