Specificity of phospholipase D activation by cholecystokinin and phorbol myristate acetate but not by carbamylcholine and A23187 in rat pancreatic acini

• Published in: Digestion Vol. 56; no. 2; p. 127
• Main Authors: Rydzewska, G, Morisset, J
• Format: Journal Article
• Language: English
• Published: Switzerland 1995
• Subjects: Alkaloids - pharmacology; Animals; Calcimycin - pharmacology; Carbachol - pharmacology; Ceruletide - pharmacology; Cholecystokinin - pharmacology; Choline - secretion; Egtazic Acid - analogs & derivatives; Egtazic Acid - pharmacology; Enzyme Activation - drug effects; Glycerophospholipids; In Vitro Techniques; Male; Pancreas - enzymology; Pancreas - metabolism; Phosphatidic Acids - metabolism; Phospholipase D - metabolism; Phosphorylcholine - metabolism; Protein Kinase C - antagonists & inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Terpenes - pharmacology; Tetradecanoylphorbol Acetate - pharmacology; Type C Phospholipases - antagonists & inhibitors

The gastrointestinal hormone cholecystokinin and the muscarinic agonist carbamylcholine are involved in pancreatic enzyme secretion through phospholipase C activation and production of the second messengers inositol trisphosphate and diacylglycerol. However, cholecystokinin induces growth of the pan...