Oral Administration of Recombinant Adeno-associated Virus-mediated Bone Morphogenetic Protein-7 Suppresses CCl4-induced Hepatic Fibrosis in Mice

• Published in: Molecular therapy Vol. 20; no. 11; pp. 2043 - 2051
• Main Authors: Hao, Zhi-Ming, Cai, Min, Lv, Yi-Fei, Huang, Yan-Hua, Li, Hong-Hong
• Format: Journal Article
• Language: English
• Published: Milwaukee Elsevier Inc 01.11.2012; Elsevier Limited; Nature Publishing Group
• Subjects: Cytokines; Gastroenterology; Growth factors; Liver cirrhosis; Liver diseases; Oral administration; Original; Proteins; Signal transduction; China

Fibrogenesis and hepatocyte degeneration are the main pathological processes in chronic liver diseases. Transforming growth factor-β1 (TGF-β1) is the key profibrotic cytokine in hepatic fibrosis. Bone morphogenetic protein-7 (BMP-7) is a potent antagonist of TGF-β1 and an antifibrotic factor. In thi...