Incidence of preleukemic fusion genes in healthy subjects

• Published in: Neoplasma Vol. 63; no. 5; p. 659
• Main Authors: Kosik, P, Skorvaga, M, Belyaev, I
• Format: Journal Article
• Language: English
• Published: Slovakia 2016
• Subjects: Core Binding Factor Alpha 2 Subunit - blood; Core Binding Factor Alpha 2 Subunit - genetics; Fetal Blood; Fusion Proteins, bcr-abl - blood; Fusion Proteins, bcr-abl - genetics; Humans; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - genetics; Mass Screening - methods; Myeloid-Lymphoid Leukemia Protein - blood; Myeloid-Lymphoid Leukemia Protein - genetics; Oncogene Proteins, Fusion - blood; Oncogene Proteins, Fusion - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; RUNX1 Translocation Partner 1 Protein - blood; RUNX1 Translocation Partner 1 Protein - genetics; childhood leukemia; stem cells; preleukemic fusion genes

The diagnostics of leukemia relies upon multi-parametric approach involving a number of different pathology disciplines such as flow cytometry, histopathology, cytogenetics and molecular genetics [fluorescent in situ hybridization (FISH) and polymerase chain reaction (PCR)]. Childhood leukemia is of...