Factor-augmented transformation models for interval-censored failure time data

• Published in: Biometrics Vol. 80; no. 3
• Main Authors: Li, Hongxi, Li, Shuwei, Sun, Liuquan, Song, Xinyuan
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.07.2024
• Subjects: Algorithms; Alzheimer Disease; Computer Simulation; Data Interpretation, Statistical; Factor Analysis, Statistical; Humans; Likelihood Functions; Models, Statistical; Neuroimaging; Time Factors; factor analysis; nonparametric maximum likelihood estimation; expectation-maximization algorithm; interval censoring; joint model
• DOI: 10.1093/biomtc/ujae078
• ISSN: 0006-341X; 1541-0420

Interval-censored failure time data frequently arise in various scientific studies where each subject experiences periodical examinations for the occurrence of the failure event of interest, and the failure time is only known to lie in a specific time interval. In addition, collected data may include multiple observed variables with a certain degree of correlation, leading to severe multicollinearity issues. This work proposes a factor-augmented transformation model to analyze interval-censored failure time data while reducing model dimensionality and avoiding multicollinearity elicited by multiple correlated covariates. We provide a joint modeling framework by comprising a factor analysis model to group multiple observed variables into a few latent factors and a class of semiparametric transformation models with the augmented factors to examine their and other covariate effects on the failure event. Furthermore, we propose a nonparametric maximum likelihood estimation approach and develop a computationally stable and reliable expectation-maximization algorithm for its implementation. We establish the asymptotic properties of the proposed estimators and conduct simulation studies to assess the empirical performance of the proposed method. An application to the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study is provided. An R package ICTransCFA is also available for practitioners. Data used in preparation of this article were obtained from the ADNI database.