Aptasensors for full body health checkup

In the last couple of decades, aptamers have been one of the preferred biomolecular recognition elements in biosensors. The platform of aptasensors (aptamer-based biosensors) is demonstrated to solve practical research problems in various areas. Aptamers and biosensors altogether gift a specific, se...

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Published inBiosensors and bioelectronics. X Vol. 11; p. 100199
Main Authors Bhardwaj, Tanu, Kumar Sharma, Tarun
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2022
Elsevier
Subjects
Aptamer
Aptasensors
Biosensor
Diagnostics
Full body checkup
SELEX
Full body checkup
Aptamer
Diagnostics
Aptasensors
Biosensor
SELEX
Online AccessGet full text
ISSN2590-1370
2590-1370
DOI10.1016/j.biosx.2022.100199

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Abstract In the last couple of decades, aptamers have been one of the preferred biomolecular recognition elements in biosensors. The platform of aptasensors (aptamer-based biosensors) is demonstrated to solve practical research problems in various areas. Aptamers and biosensors altogether gift a specific, selective, sensitive, affordable, easy to operate, robust, rapid, stable, and low sample volume analytical platform. In diagnostics, numerous review articles are published discussing the detection of various types of non-infectious and infectious diseases using aptasensors, but to the best of our knowledge, no one has reviewed the available information from the perspective of the utility of aptasensors for a full body health checkup. Therefore, to bridge this existing gap in knowledge in terms of the utility of aptasensors for full body health checkup and to provide a new perspective to the aptasensor community, in this review article, we are reviewing a battery of aptasensors, which has been utilized to detect biomarkers that correlate well with an individual's health status. Our motive in this review is to demonstrate the expansion of utility of aptasensors in routine full body checkups. Systematic Evolution of Ligands by Exponential Enrichment (SELEX), design configurations, and various detection methods employed for aptasensors are also discussed. Along with, the existing gap in the field, current challenges, and future of aptamers in diagnostics with concluding remarks are also presented in this review article. •First review on application of aptasensors for full body health checkup.•Existing gap in the application of aptasensors for human health is discussed.•Future of aptasensors is also discussed.•Few recommendations and useful suggestions are also made in the manuscript to help aptamer community for creating next generation aptasensors.
AbstractList In the last couple of decades, aptamers have been one of the preferred biomolecular recognition elements in biosensors. The platform of aptasensors (aptamer-based biosensors) is demonstrated to solve practical research problems in various areas. Aptamers and biosensors altogether gift a specific, selective, sensitive, affordable, easy to operate, robust, rapid, stable, and low sample volume analytical platform. In diagnostics, numerous review articles are published discussing the detection of various types of non-infectious and infectious diseases using aptasensors, but to the best of our knowledge, no one has reviewed the available information from the perspective of the utility of aptasensors for a full body health checkup. Therefore, to bridge this existing gap in knowledge in terms of the utility of aptasensors for full body health checkup and to provide a new perspective to the aptasensor community, in this review article, we are reviewing a battery of aptasensors, which has been utilized to detect biomarkers that correlate well with an individual's health status. Our motive in this review is to demonstrate the expansion of utility of aptasensors in routine full body checkups. Systematic Evolution of Ligands by Exponential Enrichment (SELEX), design configurations, and various detection methods employed for aptasensors are also discussed. Along with, the existing gap in the field, current challenges, and future of aptamers in diagnostics with concluding remarks are also presented in this review article.
In the last couple of decades, aptamers have been one of the preferred biomolecular recognition elements in biosensors. The platform of aptasensors (aptamer-based biosensors) is demonstrated to solve practical research problems in various areas. Aptamers and biosensors altogether gift a specific, selective, sensitive, affordable, easy to operate, robust, rapid, stable, and low sample volume analytical platform. In diagnostics, numerous review articles are published discussing the detection of various types of non-infectious and infectious diseases using aptasensors, but to the best of our knowledge, no one has reviewed the available information from the perspective of the utility of aptasensors for a full body health checkup. Therefore, to bridge this existing gap in knowledge in terms of the utility of aptasensors for full body health checkup and to provide a new perspective to the aptasensor community, in this review article, we are reviewing a battery of aptasensors, which has been utilized to detect biomarkers that correlate well with an individual's health status. Our motive in this review is to demonstrate the expansion of utility of aptasensors in routine full body checkups. Systematic Evolution of Ligands by Exponential Enrichment (SELEX), design configurations, and various detection methods employed for aptasensors are also discussed. Along with, the existing gap in the field, current challenges, and future of aptamers in diagnostics with concluding remarks are also presented in this review article. •First review on application of aptasensors for full body health checkup.•Existing gap in the application of aptasensors for human health is discussed.•Future of aptasensors is also discussed.•Few recommendations and useful suggestions are also made in the manuscript to help aptamer community for creating next generation aptasensors.
ArticleNumber 100199
Author Kumar Sharma, Tarun
Bhardwaj, Tanu
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  surname: Bhardwaj
  fullname: Bhardwaj, Tanu
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  givenname: Tarun
  orcidid: 0000-0002-0065-6099
  surname: Kumar Sharma
  fullname: Kumar Sharma, Tarun
  email: tarun.sharma@gbu.edu.in
  organization: Department of Medical Biotechnology, Gujarat Biotechnology University, Gujarat International Finance and Tec (GIFT) City, Gandhinagar, Gujarat, 382355, India
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Keywords Full body checkup
Aptamer
Diagnostics
Aptasensors
Biosensor
SELEX
Language English
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Snippet In the last couple of decades, aptamers have been one of the preferred biomolecular recognition elements in biosensors. The platform of aptasensors...
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SubjectTerms Aptamer
Aptasensors
Biosensor
Diagnostics
Full body checkup
SELEX
Title Aptasensors for full body health checkup
URI https://dx.doi.org/10.1016/j.biosx.2022.100199
https://doaj.org/article/5ec04283337f4681a81a8b855ddc5d38
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