Definition, Characterization, and Modeling of Hybrid Modular‐Monolithic Process Plants
The modularization of production plants and their automation in the pharmaceutical and (bio‐)chemical industry is currently gaining attention and is subject of standardization efforts. The combination of modular and monolithic (bio‐)chemical plants and related engineering processes, i.e., hybrid pro...
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| Published in | Chemie ingenieur technik Vol. 94; no. 8; pp. 1117 - 1130 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
01.08.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-286X 1522-2640 |
| DOI | 10.1002/cite.202200048 |
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| Abstract | The modularization of production plants and their automation in the pharmaceutical and (bio‐)chemical industry is currently gaining attention and is subject of standardization efforts. The combination of modular and monolithic (bio‐)chemical plants and related engineering processes, i.e., hybrid process plants and hybrid engineering, respectively, offers advantages in production flexibility and time to operation. However, combining the different approaches is full of hurdles and unsolved issues. In this paper, hybrid process plants are defined and characterized in a process systems framework. Modeling and simulation requirements are elaborated for the engineering workflow of hybrid process plants. The contribution concludes with summarizing current research topics and pointing to a future research agenda.
The combination of modular and monolithic (bio‐)chemical plants and related engineering processes, defined as hybrid process plants and hybrid engineering, respectively, offers advantages in production flexibility and time to operation. Current research topics are summarized and future research directions are pointed out. |
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| AbstractList | The modularization of production plants and their automation in the pharmaceutical and (bio‐)chemical industry is currently gaining attention and is subject of standardization efforts. The combination of modular and monolithic (bio‐)chemical plants and related engineering processes, i.e., hybrid process plants and hybrid engineering, respectively, offers advantages in production flexibility and time to operation. However, combining the different approaches is full of hurdles and unsolved issues. In this paper, hybrid process plants are defined and characterized in a process systems framework. Modeling and simulation requirements are elaborated for the engineering workflow of hybrid process plants. The contribution concludes with summarizing current research topics and pointing to a future research agenda.
The combination of modular and monolithic (bio‐)chemical plants and related engineering processes, defined as hybrid process plants and hybrid engineering, respectively, offers advantages in production flexibility and time to operation. Current research topics are summarized and future research directions are pointed out. The modularization of production plants and their automation in the pharmaceutical and (bio‐)chemical industry is currently gaining attention and is subject of standardization efforts. The combination of modular and monolithic (bio‐)chemical plants and related engineering processes, i.e., hybrid process plants and hybrid engineering, respectively, offers advantages in production flexibility and time to operation. However, combining the different approaches is full of hurdles and unsolved issues. In this paper, hybrid process plants are defined and characterized in a process systems framework. Modeling and simulation requirements are elaborated for the engineering workflow of hybrid process plants. The contribution concludes with summarizing current research topics and pointing to a future research agenda. |
| Author | Kockmann, Norbert Markaj, Artan Fay, Alexander |
| Author_xml | – sequence: 1 givenname: Artan surname: Markaj fullname: Markaj, Artan email: artan.markaj@hsu-hh.de organization: Helmut Schmidt University Hamburg – sequence: 2 givenname: Alexander surname: Fay fullname: Fay, Alexander organization: Helmut Schmidt University Hamburg – sequence: 3 givenname: Norbert surname: Kockmann fullname: Kockmann, Norbert organization: TU Dortmund University |
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| References | 2021; 69 2022; 178 2018; 29 2017; 63 2019; 5 2020; 63 2013; 21 2010 2019; 12 2019; 58 1998 2007 2006 1994 2017; 111 2021; 93 2005; 28 2019; 2351 2007; 15 2021; 13 2013; 36 2016; 3 2014; 2 2019; 61 2019; 42 2022 2021 2017; 38 2020 2021; 138 2020; 92 2015; 87 2011; 50 2019 2018 2017 2016 2014 2013 2018; 54 2021; 63 2012; 22 2020; 2375 2012; 42 2012; 84 e_1_2_9_31_1 e_1_2_9_52_1 e_1_2_9_50_1 e_1_2_9_73_1 e_1_2_9_10_1 e_1_2_9_35_1 e_1_2_9_56_1 e_1_2_9_12_1 e_1_2_9_33_1 Baldwin C. (e_1_2_9_19_1) 2006 e_1_2_9_71_1 Colombo A.‐W. (e_1_2_9_54_1) 2010 Rauch J. (e_1_2_9_4_1) 1998 e_1_2_9_39_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_58_1 e_1_2_9_18_1 e_1_2_9_41_1 e_1_2_9_64_1 e_1_2_9_20_1 e_1_2_9_62_1 e_1_2_9_22_1 e_1_2_9_45_1 e_1_2_9_68_1 e_1_2_9_24_1 e_1_2_9_43_1 e_1_2_9_66_1 e_1_2_9_8_1 e_1_2_9_6_1 e_1_2_9_60_1 e_1_2_9_2_1 Hessel V. (e_1_2_9_67_1) 2014 e_1_2_9_26_1 e_1_2_9_49_1 e_1_2_9_28_1 e_1_2_9_47_1 e_1_2_9_30_1 e_1_2_9_53_1 e_1_2_9_51_1 e_1_2_9_72_1 e_1_2_9_11_1 e_1_2_9_34_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_55_1 e_1_2_9_70_1 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_17_1 e_1_2_9_36_1 e_1_2_9_59_1 e_1_2_9_42_1 e_1_2_9_63_1 e_1_2_9_40_1 e_1_2_9_61_1 e_1_2_9_21_1 e_1_2_9_46_1 e_1_2_9_23_1 e_1_2_9_44_1 e_1_2_9_65_1 e_1_2_9_7_1 Southworth M. (e_1_2_9_14_1) 2013 Henter M. (e_1_2_9_57_1) 2021; 63 e_1_2_9_5_1 e_1_2_9_3_1 e_1_2_9_9_1 e_1_2_9_25_1 e_1_2_9_27_1 e_1_2_9_48_1 e_1_2_9_69_1 e_1_2_9_29_1 |
| References_xml | – volume: 63 start-page: 365 issue: 2 year: 2020 end-page: 375 article-title: A Standard Description of the Terms Module and Modularity for Systems Engineering publication-title: IEEE Trans. Eng. Manage. – volume: 58 start-page: 11154 issue: 33 year: 2019 end-page: 11159 article-title: An Industry in Transition: The Chemical Industry and the Megatrends Driving Its Forthcoming Transformation publication-title: Angew. Chem., Int. Ed. – volume: 63 start-page: 4262 issue: 10 year: 2017 end-page: 4272 article-title: Modular Manufacturing Processes: Status, Challenges, and Opportunities publication-title: AIChE J. – volume: 111 start-page: 115 year: 2017 end-page: 126 article-title: Modules in Process Industry – A Life Cycle Definition publication-title: Chem. Eng. Process. – volume: 54 start-page: 1870 issue: 2 year: 2018 end-page: 1880 article-title: Integration of Modular Process Units Into Process Control Systems publication-title: IEEE Trans. Ind. Appl. – volume: 63 start-page: 37 issue: 10 year: 2021 end-page: 43 article-title: Praktische Anwendungsfälle der modularen Produktion für die Interaktion von PEA und POL publication-title: atp Mag. – volume: 22 start-page: 935 year: 2012 end-page: 956 article-title: Optimal Modularity: A Demonstration of the Evolutionary Advantage of Modular Architectures publication-title: J. Evol. Econ. – volume: 87 start-page: 1159 issue: 9 year: 2015 end-page: 1172 article-title: No‐Regret Solutions – Modulare Produktionskonzepte für komplexe, unsichere Zeiten publication-title: Chem. Ing. Tech. – volume: 92 start-page: 192 issue: 3 year: 2020 end-page: 198 article-title: The Digital Twin – Your Ingenious Companion for Process Engineering and Smart Production publication-title: Chem. Ing. Tech. – volume: 50 start-page: 1017 year: 2011 end-page: 1026 article-title: Scale‐Up Concept for Modular Microstructured Reactors Based on Mixing, Heat Transfer, and Reactor Safety publication-title: Chem. Eng. Proc. – year: 2007 – volume: 36 start-page: 900 issue: 6 year: 2013 end-page: 910 article-title: Future Production Concepts in the Chemical Industry: Modular – Small‐Scale – Continuous publication-title: Chem. Eng. Technol. – year: 2021 – volume: 5 year: 2019 article-title: Model‐Based Systems Engineering in Modular Design publication-title: Des. Sci. – volume: 42 start-page: 2282 issue: 11 year: 2019 end-page: 2291 article-title: Orchestration Requirements for Modular Process Plants in Chemical and Pharmaceutical Industries publication-title: Chem. Eng. Technol. – volume: 87 start-page: 1173 issue: 9 year: 2015 end-page: 1184 article-title: Modulare chemische Reaktoren für die Prozessentwicklung und Produktion in kontinuierlichen Mehrzweckanlagen publication-title: Chem. Ing. Tech. – year: 2016 – volume: 15 start-page: 113 issue: 2 year: 2007 end-page: 126 article-title: Degree of Modularity in Engineering Systems and Products with Technical and Business Constraints publication-title: Concurrent Eng. Res. Appl. – volume: 178 start-page: 232 year: 2022 end-page: 250 article-title: Miniaturized Draft Tube Baffle Crystallizer for Continuous Cooling Crystallization publication-title: Chem. Eng. Res. Des. – year: 2018 – volume: 2351 start-page: 229 year: 2019 end-page: 242 article-title: Co‐Simulation‐Based Virtual Commissioning for Modular Process Plants publication-title: Automation – year: 1994 – year: 2014 – volume: 93 start-page: 2105 issue: 12 year: 2021 end-page: 2115 article-title: Towards a Systematic Data Harmonization to Enable AI Application in the Process Industry publication-title: Chem. Ing. Tech. – volume: 42 start-page: 101 issue: 1 year: 2012 end-page: 111 article-title: Model‐Based Systems Engineering: An Emerging Approach for Modern Systems publication-title: IEEE Trans. Syst. Man Cybern., Part C – year: 1998 – year: 2010 – volume: 138 start-page: 462 issue: 7 year: 2021 end-page: 468 article-title: Safety in Modular Process Plants: Demonstration of Safety Concepts publication-title: Elektrotech. Informationstech. – volume: 84 start-page: 646 issue: 5 year: 2012 end-page: 659 article-title: Scale‐up‐fähiges Equipment für die Prozessentwicklung publication-title: Chem. Ing. Tech. – volume: 69 start-page: 1040 issue: 12 year: 2021 end-page: 1050 article-title: Semantic Function Module Pipeline Generation publication-title: Automatisierungstechnik – volume: 29 start-page: 123 year: 2018 end-page: 141 article-title: Pareto‐Optimization of Complex System Architecture for Structural Complexity and Modularity publication-title: Res. Eng. Des. – start-page: 1393 year: 2020 end-page: 1396 – volume: 28 start-page: 401 issue: 4 year: 2005 end-page: 407 article-title: Mixers with Microstructured Foils for Chemical Production Purposes publication-title: Chem. Eng. Technol. – volume: 12 start-page: 281 issue: 1 year: 2019 end-page: 289 article-title: Simultaneous Production of Biomethane and Food Grade CO from Biogas: An Industrial Case Study publication-title: Energy Environ. Sci. – volume: 2 start-page: 265 issue: 1 year: 2014 end-page: 292 article-title: Selection of Technical Reactor Equipment for Modular, Continuous Small‐Scale Plants publication-title: Processes – volume: 38 start-page: 1316 issue: 14–15 year: 2017 end-page: 1330 article-title: Transport Phenomena and Chemical Reactions in Modular Microstructured Devices publication-title: Heat Transfer Eng. – volume: 61 start-page: 56 issue: 1–2 year: 2019 end-page: 69 article-title: Plug & Produce auf dem Sprung in den Markt publication-title: atp Mag. – volume: 2375 start-page: 181 year: 2020 end-page: 196 article-title: Module Management System for Administration of PEAs publication-title: Automation – year: 2022 – year: 2006 – volume: 21 start-page: 218 issue: 2 year: 2013 end-page: 230 article-title: Automated Generation of Simulation Models for Control Code Tests publication-title: Control Eng. Pract. – volume: 93 start-page: 1930 issue: 12 year: 2021 end-page: 1936 article-title: Machine Learning Based Suggestions of Separation Units for Process Synthesis in Process Simulation publication-title: Chem. Ing. Tech. – year: 2017 – volume: 3 start-page: 5 issue: 1 year: 2016 end-page: 15 article-title: Modular Equipment for Chemical Process Development and Small‐Scale Production in Multipurpose Plants publication-title: ChemBioEng Rev. – year: 2019 – volume: 13 start-page: 3223 issue: 14 year: 2021 end-page: 3236 article-title: A Unified Research Data Infrastructure for Catalysis Research – Challenges and Concepts publication-title: ChemCatChem – year: 2013 – start-page: 2935 year: 2018 end-page: 2940 – ident: e_1_2_9_73_1 doi: 10.1002/cite.202100082 – volume-title: Streets and the Shaping of Towns and Cities year: 2013 ident: e_1_2_9_14_1 – ident: e_1_2_9_44_1 doi: 10.1080/01457632.2016.1242966 – ident: e_1_2_9_46_1 doi: 10.1002/cite.201500028 – ident: e_1_2_9_65_1 – ident: e_1_2_9_17_1 – ident: e_1_2_9_31_1 doi: 10.1109/ETFA45728.2021.9613714 – ident: e_1_2_9_71_1 doi: 10.1016/j.conengprac.2012.09.022 – ident: e_1_2_9_45_1 doi: 10.3390/pr2010265 – ident: e_1_2_9_61_1 doi: 10.1109/ETFA45728.2021.9613496 – ident: e_1_2_9_42_1 doi: 10.2307/j.ctv2cw0t0f.11 – ident: e_1_2_9_22_1 doi: 10.1002/cite.202100203 – ident: e_1_2_9_26_1 doi: 10.1002/ceat.200407163 – ident: e_1_2_9_39_1 – ident: e_1_2_9_51_1 – ident: e_1_2_9_62_1 doi: 10.1109/ETFA46521.2020.9212082 – ident: e_1_2_9_24_1 doi: 10.1002/9780470125007 – ident: e_1_2_9_56_1 doi: 10.51202/9783181023754‐181 – volume: 63 start-page: 37 issue: 10 year: 2021 ident: e_1_2_9_57_1 article-title: Praktische Anwendungsfälle der modularen Produktion für die Interaktion von PEA und POL publication-title: atp Mag. – ident: e_1_2_9_38_1 – ident: e_1_2_9_66_1 – ident: e_1_2_9_72_1 doi: 10.1002/cite.201900168 – ident: e_1_2_9_43_1 doi: 10.1016/j.cep.2011.05.021 – ident: e_1_2_9_35_1 – ident: e_1_2_9_52_1 – ident: e_1_2_9_12_1 doi: 10.1002/aic.15872 – ident: e_1_2_9_20_1 doi: 10.1017/dsj.2019.15 – ident: e_1_2_9_8_1 – ident: e_1_2_9_41_1 – ident: e_1_2_9_63_1 doi: 10.1515/auto‐2021‐0090 – ident: e_1_2_9_30_1 – ident: e_1_2_9_49_1 doi: 10.1109/ETFA.2016.7733651 – ident: e_1_2_9_50_1 doi: 10.1109/IECON.2018.8591300 – ident: e_1_2_9_21_1 doi: 10.1007/s00163‐017‐0260‐9 – volume-title: Mehrprodukteanlagen year: 1998 ident: e_1_2_9_4_1 – ident: e_1_2_9_11_1 – ident: e_1_2_9_68_1 doi: 10.1109/TSMCC.2011.2106495 – ident: e_1_2_9_25_1 doi: 10.1007/978-3-322-90352-5 – ident: e_1_2_9_33_1 doi: 10.1002/cben.201500025 – ident: e_1_2_9_34_1 doi: 10.1002/ceat.201200631 – ident: e_1_2_9_28_1 – ident: e_1_2_9_6_1 – ident: e_1_2_9_15_1 doi: 10.1109/TEM.2018.2878589 – volume-title: Artificial Intelligence Techniques for Networked Manufacturing Enterprise Management year: 2010 ident: e_1_2_9_54_1 – volume-title: Complex Engineered Systems: Science Meets Technology year: 2006 ident: e_1_2_9_19_1 – ident: e_1_2_9_60_1 doi: 10.1007/s00502‐021‐00928‐8 – ident: e_1_2_9_7_1 – ident: e_1_2_9_27_1 doi: 10.1109/ETFA45728.2021.9613203 – ident: e_1_2_9_36_1 – ident: e_1_2_9_40_1 – ident: e_1_2_9_23_1 doi: 10.1353/book.66187 – ident: e_1_2_9_18_1 doi: 10.1177/2F1063293X07078931 – ident: e_1_2_9_69_1 doi: 10.1002/cctc.202001974 – ident: e_1_2_9_10_1 – ident: e_1_2_9_13_1 doi: 10.2307/j.ctv2cw0t0f.11 – ident: e_1_2_9_29_1 doi: 10.1039/C8EE02897D – ident: e_1_2_9_2_1 doi: 10.1002/anie.201905032 – ident: e_1_2_9_53_1 doi: 10.17560/atp.v61i1‐2.2400 – ident: e_1_2_9_59_1 doi: 10.1002/ceat.201900298 – ident: e_1_2_9_3_1 doi: 10.1002/cite.201400133 – ident: e_1_2_9_47_1 doi: 10.1016/j.cherd.2021.12.024 – ident: e_1_2_9_48_1 doi: 10.1109/TIA.2017.2782679 – ident: e_1_2_9_58_1 doi: 10.51202/9783181023518‐229 – ident: e_1_2_9_55_1 doi: 10.1109/ETFA45728.2021.9613711 – ident: e_1_2_9_16_1 doi: 10.1007/s00191‐011‐0240‐6 – volume-title: Novel Process Windows: Innovative Gates to Intensified and Sustainable Chemical Processes year: 2014 ident: e_1_2_9_67_1 doi: 10.1002/9783527654826 – ident: e_1_2_9_32_1 doi: 10.1002/cite.201100218 – ident: e_1_2_9_37_1 – ident: e_1_2_9_5_1 doi: 10.1016/j.cep.2016.09.017 – ident: e_1_2_9_9_1 – ident: e_1_2_9_64_1 – ident: e_1_2_9_70_1 doi: 10.1007/978-3-031-12285-9_10 |
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| SubjectTerms | Hybrid plants Modular automation Modular plants Monolithic plants Process engineering |
| Title | Definition, Characterization, and Modeling of Hybrid Modular‐Monolithic Process Plants |
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