Topical skin therapies in subjects undergoing full facial rejuvenation

• Published in: Journal of cosmetic dermatology Vol. 18; no. 3; pp. 798 - 805
• Main Authors: Dayan, Steven H., Bacos, Jonathan T., Ho, Thuy‐Van T., Gandhi, Nimit D., Gutierrez‐Borst, Selika, Kalbag, Arjun
• Format: Journal Article
• Language: English
• Published: England 01.06.2019
• Subjects: Administration, Cutaneous; Adult; botulinum toxin; Botulinum Toxins, Type A - administration & dosage; Combined Modality Therapy - methods; Cosmeceuticals - administration & dosage; Cosmetic Techniques; Dermal Fillers - administration & dosage; epidermal growth factor; Face; Female; Healthy Volunteers; Humans; hyaluronic acid; Hyaluronic Acid - administration & dosage; Injections, Subcutaneous; l‐ascorbic acid; Middle Aged; Patient Satisfaction; Rejuvenation; Self Concept; Skin Aging - drug effects; Skin Care - methods; tocopherol; Treatment Outcome; trichloroacetic acid; botulinum toxin; l-ascorbic acid; tocopherol; epidermal growth factor; hyaluronic acid; trichloroacetic acid
• DOI: 10.1111/jocd.12977
• ISSN: 1473-2130; 1473-2165

Background Cosmeceutical therapies including face washes, moisturizers, chemical peels and antioxidant formulations are intended to improve the esthetic appearance of skin. The use of these products as adjuncts to full facial rejuvenation with hyaluronic acid filler and abobotulinumtoxinA may improve cosmetic and socio‐esthetic outcomes. Objective To characterize the effect of skin care products in subjects undergoing full facial rejuvenation with abobotulinumtoxinA and hyaluronic acid in improving facial skin appearance, patient satisfaction, and projected first impressions. Methods Twenty subjects were recruited and divided into two treatment groups. Subjects in Group A followed a standard skin care regimen, whereas subjects in Group B received a more robust skin care regimen including chemical peels and antioxidant formulations. All subjects underwent facial rejuvenation treatments with hyaluronic acid at Visit 2 and with abobotulinumtoxinA at Visit 7. Patient esthetic improvement, satisfaction, self‐esteem, and first impression were evaluated via the Fitzpatrick Wrinkle Assessment Scale, Global Aesthetic Improvement Scale, Skin Quality Assessment, Heatherton & Polivy State Self‐Esteem Scale, Subject Satisfaction Scale, and the First Impressions Questionnaire. Results Both treatment groups experienced significant improvements in the Skin Quality Assessment, Fitzpatrick Wrinkle Assessment Scale, Heatherton and Polivy State Self‐Esteem Scale, and First Impressions Questionnaire. Conclusion The cosmeceutical therapies used in this study in combination with abobotulinumtoxinA and hyaluronic acid filler improved subjects’ skin quality, self‐esteem, and projected first impressions. Larger studies are needed to determine the most efficacious combination of topical skin therapies with facial rejuvenation therapy.