Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration

• Published in: Journal of cosmetic dermatology Vol. 18; no. 4; pp. 1083 - 1091
• Main Authors: Kang, Geonwoo, Kim, Suyong, Yang, Huisuk, Jang, Mingyu, Chiang, Liching, Baek, Ji Hwoon, Ryu, Ja Hyun, Choi, Go Woon, Jung, Hyungil
• Format: Journal Article
• Language: English
• Published: England 01.08.2019
• Subjects: adenosine; Adenosine - administration & dosage; Adenosine - adverse effects; Administration, Cutaneous; clinical trial; Combined Modality Therapy - adverse effects; Combined Modality Therapy - methods; Cosmetic Techniques - adverse effects; dissolving microneedles; Double-Blind Method; Drug Delivery Systems - adverse effects; Drug Delivery Systems - methods; Elasticity - drug effects; Face; Female; Humans; Hyaluronic Acid; micro‐channels; Middle Aged; Skin - chemistry; Skin - drug effects; Skin Aging - drug effects; Skin Cream - administration & dosage; Skin Cream - adverse effects; topical cream; Transdermal Patch - adverse effects; Treatment Outcome; adenosine; clinical trial; micro-channels; topical cream; dissolving microneedles

Summary Background Dissolving microneedles (DMNs), microscale needles with a biodegradable polymer matrix, have been widely investigated for transdermal drug delivery. However, the restricted drug loading space of DMNs limited the delivery of the desired quantity of active compounds. In this study,...