Mutagenic and Carcinogenic Significance and the Possible Induction of Lung Cancer by Nitro Aromatic Hydrocarbons in Particulate Pollutants

• Published in: Environmental health perspectives Vol. 102; no. suppl 4; pp. 107 - 110
• Main Authors: Tokiwa, Hiroshi, Sera, Nobuyuki, Nakashima, Akio, Nakashima, Koichi, Nakanishi, Yoichi, Shigematu, Nobuaki
• Format: Journal Article
• Language: English
• Published: United States National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare 01.10.1994
• Subjects: Adult; Air Pollutants - adverse effects; Animals; Carcinogenicity Tests; Carcinogens, Environmental - adverse effects; Carcinogens, Environmental - toxicity; Chickens; Coal; Combustion; Female; Humans; Liver; Lung neoplasms; Lung Neoplasms - chemically induced; Lungs; Male; Middle Aged; Mutagenicity; Mutagenicity Tests; Mutagens; Mutagens - toxicity; Nitro Compounds - adverse effects; Nitro Compounds - toxicity; Particulate matter; Polycyclic Compounds - adverse effects; Polycyclic Compounds - toxicity; Rats; Rats, Inbred F344; Salmonella typhimurium - drug effects; Symposium of Risk Assessment of Urban Air: Emissions, Exposure, Risk Identification, and Risk Quantitation. May 31-June 2, 1992 Stockholm, Sweden; Tumors

Studies of genotoxicity and carcinogenicity of nitro aromatic hydrocarbons focus on their high mutagenicity for bacteria and mammalian cells. Nitrobenzo[a]pyrenes (NBPs) and related nitroazaarenes also are extraordinarily mutagenic. 3-Nitro-6-azabenzo[a]pyren-N-oxide was found to be a more potent mu...