Identification and molecular characterization of the tubulin‐podophyllotoxin‐type lignans binding site on Giardia lamblia

• Published in: Chemical biology & drug design Vol. 94; no. 6; pp. 2031 - 2040
• Main Authors: Gutiérrez‐Gutiérrez, Filiberto, Romo‐Mancillas, Antonio, Puebla‐Pérez, Ana María, Hernández‐Hernández, José Manuel, Castillo‐Romero, Araceli
• Format: Journal Article
• Language: English
• Published: England 01.12.2019
• Subjects: antiparasitic; drugs; Giardia lamblia; lignans; microtubules; podophyllotoxin; tubulin; podophyllotoxin; Giardia lamblia; drugs; tubulin; antiparasitic; microtubules; lignans

There are several drugs for the treatment of giardiasis; however, there is a tendency for patients to abandon treatment because of drug‐related adverse effects, resulting in relapses, acquired resistance, and higher rates of treatment failure. Recently, we reported some podophyllotoxin‐type lignans...