Comparative trial of pantoprazole and ranitidine in the treatment of reflux esophagitis. Results of a German multicenter study

• Published in: Journal of clinical gastroenterology Vol. 20; no. 3; p. 192
• Main Authors: Koop, H, Schepp, W, Dammann, H G, Schneider, A, Lühmann, R, Classen, M
• Format: Journal Article
• Language: English
• Published: United States 01.04.1995
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles; Benzimidazoles - therapeutic use; Double-Blind Method; Esophagitis, Peptic - drug therapy; Female; Humans; Male; Middle Aged; Omeprazole - analogs & derivatives; Pantoprazole; Proton Pump Inhibitors; Ranitidine - therapeutic use; Sulfoxides - therapeutic use

In 249 patients with acute symptomatic reflux esophagitis grade II and III (Savary-Miller classification), we compared the efficacy and safety of pantoprazole, a newly developed proton pump inhibitor given at a once-daily dose of 40 mg, with a standard dose of the H2 receptor antagonist ranitidine (...