Clinical evaluation of the lightening effect of cytidine on hyperpigmented skin

• Published in: Journal of cosmetic dermatology Vol. 18; no. 1; pp. 278 - 285
• Main Authors: Baswan, Sudhir M., Leverett, Jesse, Pawelek, John
• Format: Journal Article
• Language: English
• Published: England 01.02.2019
• Subjects: Administration, Cutaneous; Adult; cytidine; Cytidine - administration & dosage; Cytidine - pharmacokinetics; Cytidine - therapeutic use; Double-Blind Method; Facial Dermatoses - drug therapy; Female; Humans; Hyperpigmentation - drug therapy; melanocyte; melanogenesis; Middle Aged; Permeability; skin lightening; Skin Lightening Preparations - administration & dosage; Skin Lightening Preparations - pharmacokinetics; Skin Lightening Preparations - therapeutic use; skin permeation; skin pigmentation; Young Adult; cytidine; melanogenesis; skin permeation; melanocyte; skin lightening; skin pigmentation

Summary Background Melanocytes, which reside in the basal layer of the epidermis, produce the pigment melanin in cytoplasmic organelles known as melanosomes. Melanosomes are transferred to keratinocytes which provide the color in our skin. Recently, Diwakar et  al reported the crucial roles of prote...