Combination Therapy with PIK3R3-siRNA and EGFR-TKI Erlotinib Synergistically Suppresses Glioblastoma Cell Growth In Vitro

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 22; no. 12; pp. 3993 - 4000
• Main Authors: Amini, Razieh, Karami, Hadi, Bayat, Mohammad
• Format: Journal Article
• Language: English
• Published: Thailand West Asia Organization for Cancer Prevention 01.12.2021
• Subjects: Antineoplastic Combined Chemotherapy Protocols - pharmacology; Apoptosis - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Drug Resistance, Neoplasm - drug effects; Erlotinib Hydrochloride - pharmacology; Glioblastoma - drug therapy; Glioblastoma - genetics; Humans; Phosphatidylinositol 3-Kinases - genetics; RNA, Small Interfering - pharmacology; PIK3R3; siRNA; PI3K; erlotinib; Glioblastoma

Up-regulation of PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3), the regulatory subunit of PI3K is correlated with the drug resistance of the glioblastoma cells. In the present study, the effect of PIK3R3 siRNA on erlotinib sensitivity of the U373-MG glioblastoma cells was explored. After P...