FACILE SODIUM METABISULFITE MEDIATED SYNTHESIS OF 1,2-DISUBSTITUTED BENZIMIDAZOLES AND CYTOTOXICITY EVALUATION

• Published in: Heterocycles Vol. 98; no. 5; pp. 650 - 665
• Main Authors: Bui Thi Buu Hue, Hien Minh Nguyen, Mai Van Hieu, Danh La Duc Thanh, Nguyen Hoang Son, Tran Quang De, Morita, Hiroyuki
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier 01.05.2019
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; IN-VITRO; SIRTUIN INHIBITORS; MICROWAVE-ASSISTED SYNTHESIS; MOLECULAR DOCKING; DERIVATIVES; ELECTROLUMINESCENCE; HYBRIDS

A library of twenty-four, structurally diverse, 2-substituted and 1,2-disubstituted benzimidazole derivatives (4a-x) was designed and synthesized. The benzimidazole derivatives were constructed by a one-pot condensation reaction between 1,2-phenylenediamines and aromatic aldehydes under mild oxidati...