lncRNA PAN3-AS1 Modulates Cilium Assemble Signaling Pathway Through Regulation of RPGR as a Potential MS Diagnostic Biomarker: Integrated Systems Biology Investigation

• Published in: Journal of molecular neuroscience Vol. 75; no. 2; p. 49
• Main Authors: Mostaghimi, Yasaman, Haddadi, Mohammad, Hojjati, Zohreh
• Format: Journal Article
• Language: English
• Published: New York Springer US 14.04.2025; Springer Nature B.V
• Subjects: Assembly; Autoimmune diseases; Autophagy; Bioinformatics; Biomarkers; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Cell Biology; Central nervous system; Cilia - metabolism; Degeneration; Demyelination; DNA microarrays; Dysautonomia; Enrichment; Humans; mRNA; Multiple sclerosis; Multiple Sclerosis - diagnosis; Multiple Sclerosis - genetics; Multiple Sclerosis - metabolism; Neurochemistry; Neurodegeneration; Neurology; Neurosciences; Non-coding RNA; Protein Interaction Maps; Proteins; Proteomics; Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Signal Transduction; Software; Spinal cord; Iran; Multiple sclerosis; Pathway enrichment; Microarray analysis; Long non-coding RNA

Multiple sclerosis (MS), an autoimmune condition of the central nervous system (CNS), can lead to demyelination and axonal degeneration in the brain and spinal cord, which can cause progressive neurologic disability. MS symptoms include dysautonomia and progressive decline in motor abilities. In thi...