Effects of fixed minidose warfarin on coagulation and fibrinolysis following major gynaecological surgery

• Published in: Thrombosis and haemostasis Vol. 64; no. 4; p. 511
• Main Authors: MacCallum, P K, Thomson, J M, Poller, L
• Format: Journal Article
• Language: English
• Published: Germany 28.12.1990
• Subjects: Adult; Blood Coagulation - drug effects; Double-Blind Method; Female; Fibrinolysis - drug effects; Genitalia, Female - surgery; Humans; Partial Thromboplastin Time; Prothrombin Time; Warfarin - administration & dosage

Coagulation and fibrinolytic studies have been performed in patients who were undergoing major gynaecological surgery and randomised to either fixed minidose warfarin (1 mg daily) or matched placebo. With warfarin, a prolongation of the prothrombin time was observed on day 2 which persisted for at l...