Activation of the opioid μ1, but not δ or κ, receptors is required for nicotine reinforcement in a rat model of drug self-administration

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 35; no. 1; pp. 146 - 153
• Main Authors: Liu, Xiu, Jernigan, Courtney
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 15.01.2011
• Subjects: Animals; Antagonist; Conditioning, Operant - drug effects; Dose-Response Relationship, Drug; Food Preferences - drug effects; Male; Narcotic Antagonists - pharmacology; Nicotine; Nicotine - administration & dosage; Nicotinic Agonists - administration & dosage; Opioid receptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu - metabolism; Reinforcement; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Self-administration; Opioid receptors; ANOVA; Reinforcement; Antagonist; FR; GNTI; Nicotine

There has long been an interest in examining the involvement of opioid neurotransmission in nicotine rewarding process and addiction to nicotine. Over the past 3 decades, however, clinical effort to test the effectiveness of nonselective opioid antagonists (mainly naloxone and naltrexone) for smokin...