Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity

• Published in: Clinical science (1979) Vol. 132; no. 22; pp. 2451 - 2467
• Main Authors: Nair, Soumyalekshmi, Jayabalan, Nanthini, Guanzon, Dominic, Palma, Carlos, Scholz-Romero, Katherin, Elfeky, Omar, Zuñiga, Felipe, Ormazabal, Valeska, Diaz, Emilio, Rice, Gregory E, Duncombe, Gregory, Jansson, Thomas, McIntyre, Harold David, Lappas, Martha, Salomon, Carlos
• Format: Journal Article
• Language: English
• Published: England 30.11.2018
• Subjects: microRNA; type 2 diabetes; Insulin sensitivity; exosomes; pregnancy

There is increasing evidence that miRNAs, which are enriched in nanovesicles called exosomes, are important regulators of gene expression. When compared with normal pregnancies, pregnancies with gestational diabetes mellitus (GDM) are associated with skeletal muscle insulin resistance as well as inc...