Assembly Transformation Jointly Driven by the LAP Enzyme and GSH Boosting Theranostic Capability for Effective Tumor Therapy

• Published in: ACS applied materials & interfaces Vol. 13; no. 50; pp. 59787 - 59802
• Main Authors: Wang, Anna, Fang, Jing, Ye, Shuyue, Mao, Qiulian, Zhao, Yan, Cui, Chaoxiang, Zhang, Yuqi, Feng, Yali, Li, Jiachen, He, Lei, Qiu, Ling, Shi, Haibin
• Format: Journal Article
• Language: English
• Published: United States 22.12.2021
• Subjects: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; aqueous solutions; Biocompatible Materials - chemical synthesis; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Cell Proliferation - drug effects; Cell Survival - drug effects; Chlorophyllides - chemistry; Chlorophyllides - pharmacology; condensation reactions; Drug Screening Assays, Antitumor; enzymes; fluorescence; glutathione; Glutathione - metabolism; Hep G2 Cells; Humans; leucine; Leucyl Aminopeptidase - metabolism; liver; Liver Neoplasms, Experimental - drug therapy; Liver Neoplasms, Experimental - metabolism; Liver Neoplasms, Experimental - pathology; magnetism; Materials Testing; moieties; Molecular Structure; neoplasms; Optical Imaging; oxygen; Particle Size; Photochemotherapy; photosensitizing agents; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; radiotherapy; shrinkage; Theranostic Nanomedicine; radiotherapy; smart probe; assembly transformation; stimulus-responsive; photodynamic therapy; bioimaging

Developing intelligent and morphology-transformable nanomaterials that can spatiotemporally undergo stimulus-responsive size transformation holds great promise for improving the tumor delivery efficiency of drugs . Here, we report a smart size-transformable theranostic probe Ce6-Leu consisting of a...