Chiral determination of amphetamine and related compounds using chloroformates for derivatization and high-performance liquid chromatography

• Published in: Analyst (London) Vol. 123; no. 10; pp. 2131 - 2137
• Main Authors: HERRAEZ-HERNANDEZ, R, CAMPINS-FALCO, P, TORTAJADA-GENARO, L. A
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 01.10.1998
• Subjects: Amphetamines - analysis; Analysis; Biological and medical sciences; Central Nervous System Stimulants - analysis; Chromatography, High Pressure Liquid; General pharmacology; Medical sciences; Pharmacology. Drug treatments; Sensitivity and Specificity; Stereoisomerism; Amphetamine derivatives; Pseudoephedrine; CNS stimulant; Chirality; Enantiomer; HPLC chromatography; Dosage form; Amfetamine; α-Adrenergic receptor agonist; Sympathomimetic; Derivatization; Quantitative analysis

The enantiomeric determination of amphetamine and various amphetamine-type compounds by liquid chromatography after chiral derivatization with 9-fluorenylmethyl chloroformate-L-proline (FMOC-L-Pro) is reported. The results obtained were compared with those achieved after achiral derivatization with...