Atlantic salmon IPS-1 mediates induction of IFNa1 and activation of NF-κB and localizes to mitochondria

• Published in: Developmental and comparative immunology Vol. 33; no. 11; pp. 1196 - 1204
• Main Authors: Lauksund, Silje, Svingerud, Tina, Bergan, Veronica, Robertsen, Børre
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.11.2009
• Subjects: Atlantic salmon; Cardif; Evolution; Fish; Gene regulation; Interferon; IPS-1; Marine; MAVS; Salmo salar; Virus; VISA; poly I:C; Gene regulation; RIG-I; VISA; Atlantic salmon; IPNV; Cardif; MDA5; Virus; MAVS; Evolution; Fish; IPS-1; Interferon; IRF; ISAV

The striking difference in evolution of type I IFN genes of fish and mammals poses the question of whether these genes are induced through similar or different signalling pathways in the two vertebrate groups. Previous work has shown that expression of both Atlantic salmon ( Salmo salar) IFNa1 and m...